Cell biology

Definition

Cell biology is the discipline of biological sciences that studies the structure, physiology, growth, reproduction and death of cells. Research in cell biology uses microscopic and molecular tools and examines all cell types, from unicellular organisms such as protozoa to the specialised cells that consitutute multicellular organisms.

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Latest Research and Reviews

  • Research |

    Zihni et al. discover a role for Cdc42–MRCK signalling in establishing contractility at the apical pole, which in turn controls epithelial polarity in mammalian cells and Drosophila photoreceptors.

    • Ceniz Zihni
    • , Evi Vlassaks
    • , Stephen Terry
    • , Jeremy Carlton
    • , Thomas King Chor Leung
    • , Michael Olson
    • , Franck Pichaud
    • , Maria Susana Balda
    •  & Karl Matter
  • Research |

    Horton et al. show that early Crebbp loss in haematopoietic progenitors results in a defective p53-mediated DNA damage response, leading to the accumulation of epigenetic and genetic alterations, which promote the onset of lymphoid malignancies.

    • Sarah J. Horton
    • , George Giotopoulos
    • , Haiyang Yun
    • , Shabana Vohra
    • , Olivia Sheppard
    • , Rachael Bashford-Rogers
    • , Mamunur Rashid
    • , Alexandra Clipson
    • , Wai-In Chan
    • , Daniel Sasca
    • , Loukia Yiangou
    • , Hikari Osaki
    • , Faisal Basheer
    • , Paolo Gallipoli
    • , Natalie Burrows
    • , Ayşegül Erdem
    • , Anastasiya Sybirna
    • , Sarah Foerster
    • , Wanfeng Zhao
    • , Tonci Sustic
    • , Anna Petrunkina Harrison
    • , Elisa Laurenti
    • , Jessica Okosun
    • , Daniel Hodson
    • , Penny Wright
    • , Ken G. Smith
    • , Patrick Maxwell
    • , Jude Fitzgibbon
    • , Ming Q. Du
    • , David J. Adams
    •  & Brian J. P. Huntly
  • Research |

    Schalbetter et al. show by Hi-C and modelling that mitotic chromosome compaction in budding yeast occurs by cis-looping of chromatin, and reveal distinct roles for cohesin and condensin depending on chromatin context.

    • Stephanie Andrea Schalbetter
    • , Anton Goloborodko
    • , Geoffrey Fudenberg
    • , Jon-Matthew Belton
    • , Catrina Miles
    • , Miao Yu
    • , Job Dekker
    • , Leonid Mirny
    •  & Jonathan Baxter
  • Research | | open

    Platelets have been associated with increased tumor growth and metastasis but the mechanistic details of this interaction are still unclear. Here the authors show that platelets improve anoikis resistance of cancer cells and increase metastasis by activating Yap through a RhoA/MYPT-PP1 pathway.

    • Monika Haemmerle
    • , Morgan L. Taylor
    • , Tony Gutschner
    • , Sunila Pradeep
    • , Min Soon Cho
    • , Jianting Sheng
    • , Yasmin M. Lyons
    • , Archana S. Nagaraja
    • , Robert L. Dood
    • , Yunfei Wen
    • , Lingegowda S. Mangala
    • , Jean M. Hansen
    • , Rajesha Rupaimoole
    • , Kshipra M. Gharpure
    • , Cristian Rodriguez-Aguayo
    • , Sun Young Yim
    • , Ju-Seog Lee
    • , Cristina Ivan
    • , Wei Hu
    • , Gabriel Lopez-Berestein
    • , Stephen T. Wong
    • , Beth Y. Karlan
    • , Douglas A. Levine
    • , Jinsong Liu
    • , Vahid Afshar-Kharghan
    •  & Anil K. Sood

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