Cell biology

Definition

Cell biology is the discipline of biological sciences that studies the structure, physiology, growth, reproduction and death of cells. Research in cell biology uses microscopic and molecular tools and examines all cell types, from unicellular organisms such as protozoa to the specialised cells that consitutute multicellular organisms.

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Latest Research and Reviews

  • Reviews |

    Clinical trials are an essential aspect of drug development; however, in patients with non-castrate prostate cancer, the long natural history of the disease provides a major barrier to the introduction of new therapies. In this Review, the authors describe the potential of a novel, multi-arm, multistage, clinical trial project, with surrogate end points designed to fully reflect the effects of treatments, in transforming the treatment of patients with early stage prostate cancer, before the development of castration-resistant disease.

    • Min Yuen Teo
    • , Matthew J. O'Shaughnessy
    • , Sean M. McBride
    • , Herbert A. Vargas
    •  & Howard I. Scher
  • Research |

    Microtubule sliding driven by kinesin-14 HSET is regulated by a feedback mechanism. When microtubules start sliding apart, HSET molecules are retained in the shortening overlap, which leads to an HSET-density-dependent decrease in sliding velocity.

    • Marcus Braun
    • , Zdenek Lansky
    • , Agata Szuba
    • , Friedrich W Schwarz
    • , Aniruddha Mitra
    • , Mengfei Gao
    • , Annemarie Lüdecke
    • , Pieter Rein ten Wolde
    •  & Stefan Diez
  • Research |

    Concomitant overexpression of microRNAs miR-100 and miR-125b-1 within the host long non-coding RNA MIR100HG induces cetuximab resistance in cancer in the absence of previously associated genetic alterations. miR-100 and miR-125b target negative regulators of Wnt/β-catenin signaling and sustain drug resistance through feedback inhibition of GATA6 expression and this resistance can be overcome by pharmacological inhibition of Wnt activity. These findings, together with those by Tan et al. in the previous issue, highlight the emerging functional role of non-coding RNAs in modulating the response to anti-cancer therapies.

    • Yuanyuan Lu
    • , Xiaodi Zhao
    • , Qi Liu
    • , Cunxi Li
    • , Ramona Graves-Deal
    • , Zheng Cao
    • , Bhuminder Singh
    • , Jeffrey L Franklin
    • , Jing Wang
    • , Huaying Hu
    • , Tianying Wei
    • , Mingli Yang
    • , Timothy J Yeatman
    • , Ethan Lee
    • , Kenyi Saito-Diaz
    • , Scott Hinger
    • , James G Patton
    • , Christine H Chung
    • , Stephan Emmrich
    • , Jan-Henning Klusmann
    • , Daiming Fan
    •  & Robert J Coffey
  • Research |

    A reverse two-hybrid approach combined with massively parallel programmed mutagenesis and sequencing allows profiling protein interaction determinants at amino-acid resolution, as demonstrated by identifying interaction-disrupting mutations in a cilia protein complex associated with Bardet–Biedl syndrome.

    • Jonathan Woodsmith
    • , Luise Apelt
    • , Victoria Casado-Medrano
    • , Ziya Özkan
    • , Bernd Timmermann
    •  & Ulrich Stelzl
  • Research |

    Enrichment of biotinylated peptides using an anti-biotin antibody results in substantially improved biotinylation site identifications by mass spectrometry compared to traditional streptavidin-based biotinylated protein enrichment.

    • Namrata D Udeshi
    • , Kayvon Pedram
    • , Tanya Svinkina
    • , Shaunt Fereshetian
    • , Samuel A Myers
    • , Ozan Aygun
    • , Karsten Krug
    • , Karl Clauser
    • , Dominic Ryan
    • , Tslil Ast
    • , Vamsi K Mootha
    • , Alice Y Ting
    •  & Steven A Carr
  • Research | | open

    DNA double strand breaks can be repaired by homology-independent or homology-directed mechanisms. The choice between these pathways is a key event for genomic stability maintenance. Here the authors identify and characterize AUNIP, as a factor involved in tilting the balance towards homology repair.

    • Jiangman Lou
    • , Hongxia Chen
    • , Jinhua Han
    • , Hanqing He
    • , Michael S. Y. Huen
    • , Xin-hua Feng
    • , Ting Liu
    •  & Jun Huang

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