Apolipoprotein E (APOE) is an important regulator of lipid metabolism and is genetically associated with longevity and age-related diseases such as Alzheimer’s disease. However, the molecular mechanisms that link APOE and aging are incompletely understood. Now an article in Nature Aging reveals that nuclear APOE promotes senescence by destabilizing heterochromatin.
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Acknowledgements
L.W. is supported by National Institute on Aging grant K99AG065500. Z.D. is supported by National Institute of Health grants R35GM137889, R00AG053406, UG3CA268117, Glenn Foundation for Medical Research and AFAR, and Longevity Impetus Grant.
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Wang, L., Dou, Z. Apolipoprotein E regulates chromatin stability and senescence. Nat Aging 2, 282–284 (2022). https://doi.org/10.1038/s43587-022-00190-3
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DOI: https://doi.org/10.1038/s43587-022-00190-3
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