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Heterochromatin

Deconfining heterochromatin for expression

Lineage-specific gene expression programs in multicellular organisms are controlled by balanced ON and OFF signals, amongst which heterochromatin regulates expression by restricting activation cues. A study now provides insights into mammalian heterochromatin organisation, function and interplay with lineage-specific transcription factors.

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Fig. 1: The interplay between heterochromatin and transcription factors in gene regulation.

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Correspondence to Maria-Elena Torres-Padilla.

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Burton, A., Torres-Padilla, ME. Deconfining heterochromatin for expression. Nat Cell Biol 23, 814–816 (2021). https://doi.org/10.1038/s41556-021-00726-6

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