●Nature Insight on Cancer. 18 November (2004). This Nature Insight covers some of the current hot topics in cancer research.

●Strategies to overcome resistance to targeted protein kinase inhibitors. Daub, H., Specht, K. & Ullrich, A. Nature Reviews Drug Discovery December (2004)

While the selective inhibition of protein kinases has proved very successful for the treatment of a number of cancers, drug resistance is also a problem. This review, forming part of this month's Focus on Kinases in Cancer, addresses how structural and mechanistic insights might overcome acquired resistance.

●Targeting angiogenesis in cancer: clinical development of bevacizumab. Kerr, D. J. Nature Clinical Practice Oncology November (2004)

This review, in the first issue of Nature Clinical Practice Oncology , charts the development of bevacizumab, a humanized monoclonal antibody that targets VEGFA. This anti-angiogenic drug is currently licensed in the United States and has been used in combination with chemotherapy in a number of different tumour types.

●Stem cells bank on ATM machine. Whetton, A. D. Nature Medicine November (2004)

Reactive oxygen species can damage both macromolecules and DNA. This News and Views article discusses how the tumour-suppressor gene ATM helps protect self-renewing stems cells from this type of damage.

●Ensuring the appropriate use of genetic tests. Burke, W. & Zimmern, R. L. Nature Reviews Genetics December (2004)

The list of genes that determine susceptibility to specific cancers is increasing. How can we ensure that genetic screening is regulated and fair?

●Adhesion articulated. Mould, A. P. & Humphries, M. J. Nature 4 November (2004)

This News and Views article discusses new structural information on the 'head' region of an integrin protein. Integrins are involved in cell adhesion and are implicated in both tumour growth and metastasis. Can this new structural data aid the development of integrin-targeted drugs?

●AKAP signalling complexes: focal points in time and space. Wong, W. & Scott, J. D. Nature Reviews Molecular Cell Biology December (2004)

●A new gene on the X involved in Fanconi anemia. Rhaman, N. & Ashworth, A. Nature Genetics November (2004)

Mutation of a previously uncharacterized gene on the X-chromosome is responsible for the complementation group B phenotype of Fanconi anaemia (FA-B). These findings help to explain why FA-B has only been seen in males.