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RNA biophysics

A three-state balancing act

How do pathogens survive temperature variations? At a molecular level, one bacterial species seems to regulate gene expression in response to temperature through structural equilibria in corresponding RNA sequences. See Letter p.355

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Figure 1: Three states of a riboswitch.


  1. *This article and the paper under discussion5 were published online on 10 July 2013.


  1. Breaker, R. R. Mol. Cell 43, 867–879 (2011).

    CAS  Article  Google Scholar 

  2. Serganov, A. & Patel, D. J. Annu. Rev. Biophys. Biomol. Struct. 41, 343–370 (2012).

    CAS  Article  Google Scholar 

  3. Serganov, A. & Nudler, E. Cell 152, 17–24 (2013).

    CAS  Article  Google Scholar 

  4. Liberman, J. A. & Wedekind, J. E. Wiley Interdisc. Rev. RNA 3, 369–384 (2012).

    CAS  Article  Google Scholar 

  5. Reining, A. et al. Nature 499, 355–359 (2013).

    ADS  CAS  Article  Google Scholar 

  6. Lemay, J.-F. et al. PLoS Genet. 7, e1001278 (2011).

    CAS  Article  Google Scholar 

  7. Garst, A. D., Edwards, A. L. & Batey, R. T. Cold Spring Harb. Perspect. Biol. 3, a003533 (2011).

    Article  Google Scholar 

  8. Al-Hashimi, H. M. & Walter, N. G. Curr. Opin. Struct. Biol. 18, 321–329 (2008).

    CAS  Article  Google Scholar 

  9. Zhang, J., Lau, M. W. & Ferré-D'Amaré, A. R. Biochemistry 49, 9123–9131 (2010).

    CAS  Article  Google Scholar 

  10. Rieder, U., Kreutz, C. & Micura, R. Proc. Natl Acad. Sci. USA 107, 10804–10809 (2010).

    ADS  CAS  Article  Google Scholar 

  11. Kortmann, J. & Narberhaus, F. Nature Rev. Microbiol. 10, 255–365 (2012).

    CAS  Article  Google Scholar 

  12. Kellenberger, C. A., Wilson, S. C., Sales-Lee, J. & Hammond, M. C. J. Am. Chem. Soc. 135, 4906–4909 (2013).

    CAS  Article  Google Scholar 

  13. Sinha, J., Reyes, S. J. & Gallivan, J. P. Nature Chem. Biol. 6, 464–470 (2010).

    CAS  Article  Google Scholar 

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Correspondence to Ronald Micura.

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Micura, R. A three-state balancing act. Nature 499, 289–290 (2013).

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