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RNA biophysics

A three-state balancing act

How do pathogens survive temperature variations? At a molecular level, one bacterial species seems to regulate gene expression in response to temperature through structural equilibria in corresponding RNA sequences. See Letter p.355

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Figure 1: Three states of a riboswitch.

Notes

  1. *This article and the paper under discussion5 were published online on 10 July 2013.

References

  1. Breaker, R. R. Mol. Cell 43, 867–879 (2011).

    CAS  Article  Google Scholar 

  2. Serganov, A. & Patel, D. J. Annu. Rev. Biophys. Biomol. Struct. 41, 343–370 (2012).

    CAS  Article  Google Scholar 

  3. Serganov, A. & Nudler, E. Cell 152, 17–24 (2013).

    CAS  Article  Google Scholar 

  4. Liberman, J. A. & Wedekind, J. E. Wiley Interdisc. Rev. RNA 3, 369–384 (2012).

    CAS  Article  Google Scholar 

  5. Reining, A. et al. Nature 499, 355–359 (2013).

    ADS  CAS  Article  Google Scholar 

  6. Lemay, J.-F. et al. PLoS Genet. 7, e1001278 (2011).

    CAS  Article  Google Scholar 

  7. Garst, A. D., Edwards, A. L. & Batey, R. T. Cold Spring Harb. Perspect. Biol. 3, a003533 (2011).

    Article  Google Scholar 

  8. Al-Hashimi, H. M. & Walter, N. G. Curr. Opin. Struct. Biol. 18, 321–329 (2008).

    CAS  Article  Google Scholar 

  9. Zhang, J., Lau, M. W. & Ferré-D'Amaré, A. R. Biochemistry 49, 9123–9131 (2010).

    CAS  Article  Google Scholar 

  10. Rieder, U., Kreutz, C. & Micura, R. Proc. Natl Acad. Sci. USA 107, 10804–10809 (2010).

    ADS  CAS  Article  Google Scholar 

  11. Kortmann, J. & Narberhaus, F. Nature Rev. Microbiol. 10, 255–365 (2012).

    CAS  Article  Google Scholar 

  12. Kellenberger, C. A., Wilson, S. C., Sales-Lee, J. & Hammond, M. C. J. Am. Chem. Soc. 135, 4906–4909 (2013).

    CAS  Article  Google Scholar 

  13. Sinha, J., Reyes, S. J. & Gallivan, J. P. Nature Chem. Biol. 6, 464–470 (2010).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Ronald Micura.

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Micura, R. A three-state balancing act. Nature 499, 289–290 (2013). https://doi.org/10.1038/nature12410

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