Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

RNA biophysics

A three-state balancing act

How do pathogens survive temperature variations? At a molecular level, one bacterial species seems to regulate gene expression in response to temperature through structural equilibria in corresponding RNA sequences. See Letter p.355

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Three states of a riboswitch.

Notes

  1. *This article and the paper under discussion5 were published online on 10 July 2013.

References

  1. Breaker, R. R. Mol. Cell 43, 867–879 (2011).

    Article  CAS  Google Scholar 

  2. Serganov, A. & Patel, D. J. Annu. Rev. Biophys. Biomol. Struct. 41, 343–370 (2012).

    Article  CAS  Google Scholar 

  3. Serganov, A. & Nudler, E. Cell 152, 17–24 (2013).

    Article  CAS  Google Scholar 

  4. Liberman, J. A. & Wedekind, J. E. Wiley Interdisc. Rev. RNA 3, 369–384 (2012).

    Article  CAS  Google Scholar 

  5. Reining, A. et al. Nature 499, 355–359 (2013).

    Article  ADS  CAS  Google Scholar 

  6. Lemay, J.-F. et al. PLoS Genet. 7, e1001278 (2011).

    Article  CAS  Google Scholar 

  7. Garst, A. D., Edwards, A. L. & Batey, R. T. Cold Spring Harb. Perspect. Biol. 3, a003533 (2011).

    Article  Google Scholar 

  8. Al-Hashimi, H. M. & Walter, N. G. Curr. Opin. Struct. Biol. 18, 321–329 (2008).

    Article  CAS  Google Scholar 

  9. Zhang, J., Lau, M. W. & Ferré-D'Amaré, A. R. Biochemistry 49, 9123–9131 (2010).

    Article  CAS  Google Scholar 

  10. Rieder, U., Kreutz, C. & Micura, R. Proc. Natl Acad. Sci. USA 107, 10804–10809 (2010).

    Article  ADS  CAS  Google Scholar 

  11. Kortmann, J. & Narberhaus, F. Nature Rev. Microbiol. 10, 255–365 (2012).

    Article  CAS  Google Scholar 

  12. Kellenberger, C. A., Wilson, S. C., Sales-Lee, J. & Hammond, M. C. J. Am. Chem. Soc. 135, 4906–4909 (2013).

    Article  CAS  Google Scholar 

  13. Sinha, J., Reyes, S. J. & Gallivan, J. P. Nature Chem. Biol. 6, 464–470 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ronald Micura.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Micura, R. A three-state balancing act. Nature 499, 289–290 (2013). https://doi.org/10.1038/nature12410

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature12410

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing