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Bioinorganic chemistry

Enzymes activated by synthetic components

Synthetic analogues of the catalytic subsite of the hydrogen-producing enzyme HydA1 have been disappointingly inactive. The incorporation of such analogues into the enzyme's active site reveals the requirements for activity. See Letter p.66

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Correspondence to Ryan D. Bethel or Marcetta Y. Darensbourg.

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Bethel, R., Darensbourg, M. Enzymes activated by synthetic components. Nature 499, 40–41 (2013).

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