Synthetic analogues of the catalytic subsite of the hydrogen-producing enzyme HydA1 have been disappointingly inactive. The incorporation of such analogues into the enzyme's active site reveals the requirements for activity. See Letter p.66
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Notes
*This article and the paper under discussion1 were published online on 26 June 2013.
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Bethel, R., Darensbourg, M. Enzymes activated by synthetic components. Nature 499, 40–41 (2013). https://doi.org/10.1038/nature12260
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DOI: https://doi.org/10.1038/nature12260
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