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Manganese catalyst enables exploration of the magic methyl effect

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Nature 580, 592-593 (2020)



  1. Pritchard, J. F. et al. Nature Rev. Drug Discov. 2, 542–553 (2003).

    Article  PubMed  Google Scholar 

  2. Biopharmaceutical R&D: The Process Behind New Medicines (Pharmaceut. Res. Manufact. Am., 2015).

  3. Feng, K. et al. Nature 580, 621–627 (2020).

    Article  Google Scholar 

  4. Schönherr, H. & Cernak, T. Angew. Chem. Int. Edn 52, 12256–12267 (2013).

    Article  Google Scholar 

  5. Moir, M., Danon, J. J., Reekie, T. A. & Kassiou, M. Expert Opin. Drug Discov. 14, 1127–1149 (2019).

    Article  Google Scholar 

  6. Cernak, T., Dykstra, K. D., Tyagarajan, S., Vachal, P. & Krska, S. W. Chem. Soc. Rev. 45, 546–576 (2019).

    Article  Google Scholar 

  7. Sono, M., Roach, M. P., Coulter, E. D. & Dawson, J. H. Chem. Rev. 96, 2841–2888 (1996).

    Article  PubMed  Google Scholar 

  8. Denisov, I. G., Makris, T. M., Sligar, S. G. & Schlichting, I. Chem. Rev. 105, 2253–2278 (2005).

    Article  PubMed  Google Scholar 

  9. Chen, M. S. & White, C. Science 318, 783–787 (2007).

    Article  PubMed  Google Scholar 

  10. Zhao, J., Nanjo, T., de Lucca, E. C. & White, M. C. Nature Chem. 11, 213–221 (2019).

    Article  PubMed  Google Scholar 

Download references


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