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Bile acids are important mediators for lipid absorption, distribution, and metabolism through activation of bile acid receptor FXR. Disregulation in bile acid homeostasis and FXR function resulted in NASH. The cover art dipicts the role of FXR in bile acid regulation and the FXR structure as the basis for rational drug design for treating NASH, both topics are reviewed by Jiao et al and by Tian et al in pages 1103 and 1120, respectively.