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Proposed mechanism by which orosomucoid (ORM) is involved in adipose tissue fibrosis. ORM1-deficient mice showed significant increases in fat mass and excessive collagen deposition. Exogenous administration of ORM activates adipose tissue AMPK, inhibits TGF-β1 levels, and reduces the expression of collagen and extracellular matrix (ECM) mediators, thus alleviating adipose tissue fibrosis. See the article in pages 367–375.