Acta Pharmacologica Sinica

Structure genomics of SARS-CoV-2 and its Omicron variant

Mammalian integrated stress responses in stressed organelles and their functions

Hao-jun Lu
Nirmala Koju
Rui Sheng

Review Article 24 January 2024

Featured

Targeted inhibition of the HNF1A/SHH axis by triptolide overcomes paclitaxel resistance in non-small cell lung cancer

Ling-bing Li
Ling-xiao Yang
Xiao-gang Zhao
ArticleOpen Access16 Jan 2024
Quantitative systems pharmacology modeling of HER2-positive metastatic breast cancer for translational efficacy evaluation and combination assessment across therapeutic modalities

Ya-ting Zhou
Jia-hui Chu
Chen Zhao
ArticleOpen Access15 Feb 2024
Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching

Shi-chun Shen
Jie Xu
Li-kun Ma
Article15 Jan 2024
Transforming growth factor-β receptors: versatile mechanisms of ligand activation

Zheng-Jie Chia
Ying-nan Cao
Danielle Kamato
Review ArticleOpen Access13 Feb 2024

Current issue

Nucleic acid and protein methylation modification in renal diseases

Juan Jin
Xue-mei Liu
Xiao-ming Meng
Review Article15 Dec 2023
Autoimmune diseases: targets, biology, and drug discovery

Shu-jie Li
Yan-li Wu
H. Eric Xu
Review Article14 Dec 2023
From bench to bedside: current development and emerging trend of KRAS-targeted therapy

Yi Chen
Qiu-pei Liu
Jian Ding
Review Article04 Dec 2023
Sigma-1 receptor activation mediates the sustained antidepressant effect of ketamine in mice via increasing BDNF levels

Hui Ma
Jin-feng Li
Yun-feng Li
Article14 Dec 2023
O-GlcNAcylation mediates H₂O₂-induced apoptosis through regulation of STAT3 and FOXO1

Chen-chun Zhang
Yuan Li
Fei-fei Wang
Article08 Jan 2024
Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis

Wei Wang
Xiao-kang Chen
Liang-peng Li
Article12 Dec 2023

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Announcements

JOIN US | Deputy Director Position of SKLDR

State Key Laboratory of Drug Research (SKLDR), which was approved by Chinese Academy of Sciences under the unremitting efforts of reorganizing the state key laboratory system, is recruiting a Deputy Director. The candidate is expected to help SKLDR to continuously improve the academic influence and the ability to transform new drug achievements into real productivity.

Browse articles

Endothelial deubiquinatase YOD1 mediates Ang II-induced vascular endothelial-mesenchymal transition and remodeling by regulating β-catenin

Wan-te Lin
Yu-cheng Jiang
Guang Liang
Article19 Apr 2024
Cpd-A1 alleviates acute kidney injury by inhibiting ferroptosis

Ying Chen
Ming-fei Wu
Xiao-ming Meng
Article19 Apr 2024
Liver receptor homolog-1: structures, related diseases, and drug discovery

Tong Wu
Zhi-fang Lu
Yong Xu
Review Article17 Apr 2024
Frizzled receptors (FZDs) in Wnt signaling: potential therapeutic targets for human cancers

Hui-yu Liu
Xiao-jiao Sun
Tian-cheng Li
Review Article17 Apr 2024
Ripretinib inhibits HIV-1 transcription through modulation of PI3K-AKT-mTOR

Jin-feng Cai
Jia-sheng Zhou
Kai Deng
Article16 Apr 2024
Transcriptional regulation and post-translational modifications in the glycolytic pathway for targeted cancer therapy

Xuan Ni
Cheng-piao Lu
Jing-jing Ma
Review Article15 Apr 2024
Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma

Qi-yi Zhang
Wen Ding
Xiao-lei Zhang
Article12 Apr 2024
Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy

Zhi-feng Zou
Lei Yang
Zhi-ai Xu
Article12 Apr 2024
A novel bispecific antibody drug conjugate targeting HER2 and HER3 with potent therapeutic efficacy against breast cancer

Hui-fang Zong
Xi Li
Jian-wei Zhu
Article11 Apr 2024

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Science jobs

Postdoctoral Fellowships: Early Diagnosis and Precision Oncology of Gastrointestinal Cancers

We currently have multiple postdoctoral fellowship positions within the multidisciplinary research team headed by Dr. Ajay Goel, professor and foun...

Monrovia, California

Beckman Research Institute, City of Hope, Goel Lab
Postdoctoral Associate- Computational Spatial Biology

Houston, Texas (US)

Baylor College of Medicine (BCM)
Staff Scientist - Genetics and Genomics

Houston, Texas (US)

Baylor College of Medicine (BCM)
Technician - Senior Technician in Cell and Molecular Biology

APPLICATION CLOSING DATE: 24.05.2024 Human Technopole (HT) is a distinguished life science research institute founded and supported by the Italian ...

Milan (IT)

Human Technopole
Postdoctoral Fellow

The Dubal Laboratory of Neuroscience and Aging at the University of California, San Francisco (UCSF) seeks postdoctoral fellows to investigate the ...

San Francisco, California

University of California, San Francsico

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.

Mammalian integrated stress responses in stressed organelles and their functions

Featured

Targeted inhibition of the HNF1A/SHH axis by triptolide overcomes paclitaxel resistance in non-small cell lung cancer

Quantitative systems pharmacology modeling of HER2-positive metastatic breast cancer for translational efficacy evaluation and combination assessment across therapeutic modalities

Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching

Transforming growth factor-β receptors: versatile mechanisms of ligand activation

Current issue

Nucleic acid and protein methylation modification in renal diseases

Autoimmune diseases: targets, biology, and drug discovery

From bench to bedside: current development and emerging trend of KRAS-targeted therapy

Sigma-1 receptor activation mediates the sustained antidepressant effect of ketamine in mice via increasing BDNF levels

O-GlcNAcylation mediates H₂O₂-induced apoptosis through regulation of STAT3 and FOXO1

Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis

Announcements

JOIN US | Deputy Director Position of SKLDR

Browse articles

Endothelial deubiquinatase YOD1 mediates Ang II-induced vascular endothelial-mesenchymal transition and remodeling by regulating β-catenin

Cpd-A1 alleviates acute kidney injury by inhibiting ferroptosis

Liver receptor homolog-1: structures, related diseases, and drug discovery

Frizzled receptors (FZDs) in Wnt signaling: potential therapeutic targets for human cancers

Ripretinib inhibits HIV-1 transcription through modulation of PI3K-AKT-mTOR

Transcriptional regulation and post-translational modifications in the glycolytic pathway for targeted cancer therapy

Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma

Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy

A novel bispecific antibody drug conjugate targeting HER2 and HER3 with potent therapeutic efficacy against breast cancer

Trending - Altmetric

Science jobs

Postdoctoral Fellowships: Early Diagnosis and Precision Oncology of Gastrointestinal Cancers

Postdoctoral Associate- Computational Spatial Biology

Staff Scientist - Genetics and Genomics

Technician - Senior Technician in Cell and Molecular Biology

Postdoctoral Fellow

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Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

Organ preservation: from the past to the future

Population pharmacokinetic modeling and simulation of huperzine A in elderly Chinese subjects

Ripretinib inhibits HIV-1 transcription through modulation of PI3K-AKT-mTOR

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