Review Article |
Featured
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Research Highlight |
Gonadotropin deficiency in genetic form of congenital hypogonadotropic hypogonadism is of hypothalamic origin
- Linda Koch
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Review Article |
Environmental causes of cancer: endocrine disruptors as carcinogens
An increased incidence of malformations of the genital tract, and neoplasms of the testis, uterus, and breast has been observed during the past half century following the introduction of endocrine disrupting chemicals into the environment. This Review discusses the theoretical underpinnings and corresponding evidence connecting development and carcinogenesis. The data gathered thus far linking exposure to these chemicals to cancer warrant action to protect public health.
- Ana M. Soto
- & Carlos Sonnenschein
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Review Article |
Immunity, thyroid function and pregnancy: molecular mechanisms
Pregnancy is an immunological balancing act in which major changes in the mother's immune system occur that prevent rejection of the fetus that bears paternal antigens. This Review discusses the immunological mechanisms involved in such tolerance of the fetus, and highlights how these mechanisms may explain the clinical changes in autoimmune thyroid disease during and after pregnancy.
- Anthony P. Weetman
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Case Study |
Reevaluation of a case of type 1 diabetes mellitus diagnosed before 6 months of age
The authors of this Case Study demonstrate the substantial impact of molecular genetic testing in the improvement of diagnostics and patient treatment on the basis of the case of a 17-year-old patient who was diagnosed as having type 1 diabetes mellitus in early infancy, but after reassessment was found to have neonatal diabetes mellitus owing to a Kir6.2 mutation.
- Angus G. Jones
- & Andrew T. Hattersley
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