Organogenesis

Definition

Organogenesis is the process by which the internal organs and specific structures such as the limb are formed during development of an organism. Organogenesis involves the coordination of multiple developmental processes such as embryonic induction, pattern formation, morphogenesis, cell proliferation and differentiation.

Latest Research and Reviews

  • Research |

    Cecilia Lo and colleagues report the recovery of mice with hypoplastic left heart syndrome (HLHS) from a large mutagenesis screen. They find genetic heterogeneity among HLHS mice and functionally validate mutations in two genes, Sap130 and Pcdha, as contributing to HLHS in a combinatorial manner.

    • Xiaoqin Liu
    • , Hisato Yagi
    • , Shazina Saeed
    • , Abha S Bais
    • , George C Gabriel
    • , Zhaohan Chen
    • , Kevin A Peterson
    • , You Li
    • , Molly C Schwartz
    • , William T Reynolds
    • , Manush Saydmohammed
    • , Brian Gibbs
    • , Yijen Wu
    • , William Devine
    • , Bishwanath Chatterjee
    • , Nikolai T Klena
    • , Dennis Kostka
    • , Karen L de Mesy Bentley
    • , Madhavi K Ganapathiraju
    • , Phillip Dexheimer
    • , Linda Leatherbury
    • , Omar Khalifa
    • , Anchit Bhagat
    • , Maliha Zahid
    • , William Pu
    • , Simon Watkins
    • , Paul Grossfeld
    • , Stephen A Murray
    • , George A Porter Jr
    • , Michael Tsang
    • , Lisa J Martin
    • , D Woodrow Benson
    • , Bruce J Aronow
    •  & Cecilia W Lo
  • Research |

    Two studies by Sugden et al. and Jin et al. show that endoglin regulates endothelial cell migration through VEGFR2 signalling and controls blood vessel diameter in response to blood flow.

    • Wade W. Sugden
    • , Robert Meissner
    • , Tinri Aegerter-Wilmsen
    • , Roman Tsaryk
    • , Elvin V. Leonard
    • , Jeroen Bussmann
    • , Mailin J. Hamm
    • , Wiebke Herzog
    • , Yi Jin
    • , Lars Jakobsson
    • , Cornelia Denz
    •  & Arndt F. Siekmann
  • Reviews |

    The angiopoietin (ANG)–TIE growth factor receptor pathway regulates pathological vascular remodelling during inflammation, tumour angiogenesis and metastasis. It has become an attractive pharmacological target for oncological and ophthalmological indications, as well as sepsis, diabetic vasculopathies, organ transplantation and atherosclerosis. Here, Alitalo and colleagues provide an overview of the biology of the ANG–TIE pathway and discuss the development of therapeutics that target it.

    • Pipsa Saharinen
    • , Lauri Eklund
    •  & Kari Alitalo
  • Research | | open

    The molecular mechanism regulating macrophage interaction with endothelial cells during development is unclear. Here, the authors show that in zebrafish mutation of hypoxia-inducible factor-1α impairs macrophage mobilization from the aorta-gonad-mesonephros, causing defects in angiogenesis and vessel repair.

    • Claudia Gerri
    • , Rubén Marín-Juez
    • , Michele Marass
    • , Alora Marks
    • , Hans-Martin Maischein
    •  & Didier Y R. Stainier
  • Research | | open

    Foetal microchimeric cells (FMCs) are found in maternal circulation during pregnancy and migrate to injury sites, where they mediate repair, but how this is regulated is unclear. Here, the authors show in mice that the chemokine Ccl2 enhances delayed maternal wound healing through a subpopulation of Ccr2+ FMCs.

    • Mathieu Castela
    • , Dany Nassar
    • , Maria Sbeih
    • , Marie Jachiet
    • , Zhe Wang
    •  & Selim Aractingi

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