Lipids articles within Nature

Featured

  • Review Article |

    This Review describes the various mechanisms of ion-coupled transport across membranes and how the activities of transporter proteins are modulated by the composition of the lipid bilayer.

    • David Drew
    •  & Olga Boudker

  • Article
    | Open Access

    IL-10 exerts its anti-inflammatory activity in macrophages by increasing the expression of enzymes that promote fatty acid desaturation and downstream regulation of the transcription factor REL.

    • Autumn G. York
    • , Mathias H. Skadow
    •  & Richard A. Flavell

  • Article
    | Open Access

    Triacylglycerols are an energy source produced in humans by DGAT1 and DGAT2, but disrupting these enzymes reveals a noncanonical pathway involving the protein DIESL (formerly TMEM68) and its regulator TMX1, which is important during lipid scarcity.

    • Gian-Luca McLelland
    • , Marta Lopez-Osias
    •  & Thijn R. Brummelkamp

  • Article
    | Open Access

    Philological analysis of labels and instructions, together with gas chromatography–mass spectrometry analysis of residues on vessels recovered from a 26th Dynasty embalming workshop at Saqqara, Egypt provide insights into ancient Egyptian embalming practices.

    • Maxime Rageot
    • , Ramadan B. Hussein
    •  & Philipp W. Stockhammer

  • Article |

    Inhibiting the asialoglycoprotein receptor ASGR1 increases cholesterol excretion to the bile and then faeces, providing a unique way to lower cholesterol, and therefore providing a safe and effective way to treat cardiovascular disease.

    • Ju-Qiong Wang
    • , Liang-Liang Li
    •  & Bao-Liang Song

  • Article |

    The cellular organelles peroxisomes contribute to the sensitivity of cells to ferroptosis by synthesizing polyunsaturated ether phospholipids, and changes in the abundances of these lipids are associated with altered sensitivity to ferroptosis during cell-state transitions.

    • Yilong Zou
    • , Whitney S. Henry
    •  & Stuart L. Schreiber

  • Article |

    In xenograft tumour models in mice, modulation of dietary serine, serine palmitoyltransferase or phosphoglycerate dehydrogenase activity enables control of the endogenous synthesis of deoxysphingolipids, sensitizing the tumours to metabolic stress and slowing their progression.

    • Thangaselvam Muthusamy
    • , Thekla Cordes
    •  & Christian M. Metallo

  • Article |

    Cryo-electron microscopy structures of heterodimeric and homodimeric full-length GABAB receptors, combined with cellular signalling assays, shed light on the mechanisms that underpin signal transduction mediated by these receptors.

    • Makaía M. Papasergi-Scott
    • , Michael J. Robertson
    •  & Georgios Skiniotis

  • Article |

    A synthetic lethal CRISPR–Cas9 screen identifies ferroptosis suppressor protein 1 as a key ferroptosis-resistance factor, the expression of which correlates with ferroptosis resistance in hundreds of cancer cell lines.

    • Kirill Bersuker
    • , Joseph M. Hendricks
    •  & James A. Olzmann

  • Letter |

    Crystal structures of a five-protein complex comprising the inner-membrane components of the bacterial lipopolysaccharide transporter provide insight into the mechanism of extraction of lipopolysaccharide from the inner membrane and its transport to the outer membrane.

    • Tristan W. Owens
    • , Rebecca J. Taylor
    •  & Daniel Kahne

  • Article |

    Cryo-electron microscopy snapshots of the E. coli flippase MsbA at discrete functional states reveal a ‘trap and flip’ mechanism for lipopolysaccharide flipping and the conformational transitions of MsbA during its substrate transport cycle.

    • Wei Mi
    • , Yanyan Li
    •  & Maofu Liao

  • Letter |

    A mechanism for phosphoinositide conversion at endosomes to enable exit from the endosomal system, suggesting that defective phosphoinositide conversion at endosomes underlies X-linked centronuclear myopathy.

    • Katharina Ketel
    • , Michael Krauss
    •  & Volker Haucke

  • Letter |

    Detection of molecular biomarkers characteristic of beeswax in pottery vessels at archaeological sites reveals that humans have exploited bee products (such as beeswax and honey) at least 9,000 years ago since the beginnings of agriculture.

    • Mélanie Roffet-Salque
    • , Martine Regert
    •  & Jamel Zoughlami

  • Letter |

    Acetyl-CoA carboxylases (ACCs) are large, multi-domain enzymes with crucial functions in fatty acid metabolism and are potential drug targets; here the X-ray crystal structure of the full-length, 500-kDa holoenzyme dimer of the ACC from Saccharomyces cerevisiae is solved and reveals an organization quite different from that of other biotin-dependent carboxylases.

    • Jia Wei
    •  & Liang Tong

  • Article |

    The X-ray crystal structure of the ABC transporter PglK, which facilitates the flipping of lipid-linked oligosaccharides (LLOs) in C. jejuni, in inward- and outward-facing states is solved; the structures and follow-up biochemical experiments support an unprecedented mechanism in which the polyprenyl tail of LLO remains partially embedded in the lipid bilayer, and the pyrophosphate-oligosaccharide head group is flipped into the outward-facing cavity after ATP is hydrolysed.

    • Camilo Perez
    • , Sabina Gerber
    •  & Kaspar P. Locher

  • Letter |

    Mitochondria have essential functions within cells, and their dysfunction is linked to various disorders; here, the fatty acid stearic acid (C18:0), which is a dietary component, and the transferrin receptor (TFR1) are shown to regulate mitochondrial function.

    • Deniz Senyilmaz
    • , Sam Virtue
    •  & Aurelio A. Teleman

  • Letter |

    The crystal structure of mouse SCD1 bound to fatty acid stearoyl-CoA is solved at 2.6 Å resolution; the structure reveals a novel geometry for the dimetal centre, and the acyl chain of the bound fatty acid is shown to be shielded and shaped to a particular conformation by the enzyme, providing a structural basis for the selectivity of fatty acid metabolism.

    • Yonghong Bai
    • , Jason G. McCoy
    •  & Ming Zhou

  • Letter |

    Little is known about how individual cells within a group of cells exposed to the same external signals can produce a specific individual response to their local microenvironment; a quantitative analysis of cell crowding reveals that single cells can autonomously sense local crowding though their ability to spread and activate focal adhesion kinase (FAK), which ultimately results in changes in cellular lipid composition.

    • Mathieu Frechin
    • , Thomas Stoeger
    •  & Lucas Pelkmans

  • Article |

    This study identifies a crucial role for fatty acid oxidation (FAO) in endothelial cells during angiogenesis, and reveals that fatty-acid-derived carbons are used for the de novo synthesis of nucleotides, and hence FAO stimulates vessel sprouting by increasing endothelial cell proliferation.

    • Sandra Schoors
    • , Ulrike Bruning
    •  & Peter Carmeliet

  • Article |

    The biochemical activity of Notum as a carboxylesterase that removes an essential lipid moiety from Wnt proteins is uncovered; the interaction of Notum with glypicans is required to ensure localization at the cell surface, and Notum may provide a new target for therapeutic development in diseases with defective Wnt signalling.

    • Satoshi Kakugawa
    • , Paul F. Langton
    •  & Jean-Paul Vincent

  • Letter |

    Solving the X-ray crystal structure of a Δ14-sterol reductase and homologue of human C14SR and DHCR7, two enzymes that reduce specific carbon–carbon double bonds in the cholesterol biosynthetic pathway, may provide insight into how specific mutations in DHCR7 and lamin B receptor lead to human diseases.

    • Xiaochun Li
    • , Rita Roberti
    •  & Günter Blobel

  • Letter |

    A new mass-spectrometry method has been developed to obtain high-resolution spectra of folded proteins bound to lipids; using this technique as well as X-ray crystallography provides evidence for membrane protein conformational change as a result of lipid–protein interaction.

    • Arthur Laganowsky
    • , Eamonn Reading
    •  & Carol V. Robinson

  • Letter |

    Mfsd2a is the major transporter of the omega-3 fatty acid docosahexaenoic acid (DHA) into brain, with Mfsd2a-knockout mice showing reduced DHA in brain, neuronal cell loss in hippocampus and cerebellum, behavioural disorders and reduced brain size; DHA is transported in a sodium-dependent manner, in the form of lysophosphatidylcholines (LPCs) carrying long-chain fatty acids.

    • Long N. Nguyen
    • , Dongliang Ma
    •  & David L. Silver

  • Letter |

    A highly specific chemical crosslinking method is used to trap a complex between an acyl carrier protein and a fatty acid dehydratase during fatty acid biosynthesis; subsequent X-ray crystallography, NMR spectroscopy and molecular dynamics simulations techniques enable the detailed study of this complex.

    • Chi Nguyen
    • , Robert W. Haushalter
    •  & Michael D. Burkart

  • Letter |

    A human lipid transfer protein (GLTPD1, named here CPTP) is shown to regulate eicosanoid production by mediating the intermembrane transfer of the phosphorylated sphingolipid ceramide-1-phosphate through a non-vesicular transport mechanism elucidated by structural, functional and biological data.

    • Dhirendra K. Simanshu
    • , Ravi Kanth Kamlekar
    •  & Dinshaw J. Patel

  • Letter |

    Gene-expression studies are used to elucidate the relationship between cholesterol regulation and angiogenesis: apolipoprotein A-1 binding protein (AIBP) is found to enhance cholesterol influx from endothelial cells to high-density lipoprotein, and the resulting cholesterol depletion alters membrane lipid order in the vasculature, leading to decreased vascular endothelial growth factor receptor signalling.

    • Longhou Fang
    • , Soo-Ho Choi
    •  & Yury I. Miller

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