Sterols articles within Nature

Featured

• Article | 03 August 2022

  Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion

  Inhibiting the asialoglycoprotein receptor ASGR1 increases cholesterol excretion to the bile and then faeces, providing a unique way to lower cholesterol, and therefore providing a safe and effective way to treat cardiovascular disease.

  • Ju-Qiong Wang
  • , Liang-Liang Li
  •  & Bao-Liang Song

• Letter | 01 July 2019

  Smoothened stimulation by membrane sterols drives Hedgehog pathway activity

  The crystal structure of active mouse SMO in complex with the SAG21k agonist and a stabilizing intracellular binding nanobody reveals the structural basis of SMO regulation by PTCH1.

  • Ishan Deshpande
  • , Jiahao Liang
  •  & Aashish Manglik

• Letter | 25 July 2018

  Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination

  Many small molecules that stimulate oligodendrocyte formation act not through their canonical pathways but by inhibiting enzymes within the cholesterol biosynthesis pathway and thereby inducing the accumulation of 8,9-unsaturated sterols.

  • Zita Hubler
  • , Dharmaraja Allimuthu
  •  & Drew J. Adams

• Letter | 12 October 2014

  Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum

  Solving the X-ray crystal structure of a Δ¹⁴-sterol reductase and homologue of human C14SR and DHCR7, two enzymes that reduce specific carbon–carbon double bonds in the cholesterol biosynthetic pathway, may provide insight into how specific mutations in DHCR7 and lamin B receptor lead to human diseases.

  • Xiaochun Li
  • , Rita Roberti
  •  & Günter Blobel