Featured
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Letter |
EPRS is a critical mTORC1–S6K1 effector that influences adiposity in mice
Glutamyl-prolyl tRNA synthetase (EPRS) is a downstream effector of the mTORC1–S6K1 signalling axis and contributes to adiposity and ageing in mice.
- Abul Arif
- , Fulvia Terenzi
- & Paul L. Fox
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News & Views |
Fat, bile and gut microbes
Western-style diets could be contributing to the rapid increase in inflammatory bowel disease. New research suggests that dietary fat can alter bile composition and so favour the growth of pro-inflammatory gut microbes. See Letter p.104
- Peter J. Turnbaugh
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Letter |
A PPARγ–FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis
PPARγ induces fibroblast growth factor 1 to remodel visceral adipose tissue in response to a high-fat diet to maintain metabolic homeostasis.
- Johan W. Jonker
- , Jae Myoung Suh
- & Ronald M. Evans
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Research Highlights |
Addiction: Junk-food junkies