Leukocytes

Definition

Leukocytes are the white blood cells of the immune system that protect our tissues from infection and other forms of damage. Leukocytes can be sub-classed as cells of the innate immune system (for example, macrophages, neutrophils and dendritic cells) or of the adaptive immune system (for example, B cells and T cells).

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Latest Research and Reviews

  • Research |

    T cells developing in the thymus are signaled during positive selection to differentiate into either CD4+ T cells or CD8+ T cells. Singer and colleagues show that CD8+-lineage specification is signaled exclusively by cytokines, including cytokines that do not signal via the γc receptor, and that these are the only signals in the thymus that upregulate the transcription factor Runx3d to direct specification to the CD8+ lineage.

    • Ruth Etzensperger
    • , Tejas Kadakia
    • , Xuguang Tai
    • , Amala Alag
    • , Terry I Guinter
    • , Takeshi Egawa
    • , Batu Erman
    •  & Alfred Singer
  • Reviews |

    Here, the authors introduce the idea that a spectrum of metabolic states of immune cells can provide a basis for categorizing human diseases. They explore the metabolic and interlinked signalling requirements of T cells responding to acute infection and how metabolic reprogramming of T cells is linked to disease.

    • Glenn R. Bantug
    • , Lorenzo Galluzzi
    • , Guido Kroemer
    •  & Christoph Hess
  • Research | | open

    Developmental cues for the different dendritic cell (DC) subsets in the intestine are yet to be defined. Here the authors show that TGFβR1 signalling is needed for development of CD103+CD11b+ intestinal DCs from CD103CD11b+ cells and that they contribute to the generation of Th17 and regulatory T cells

    • C. C. Bain
    • , J. Montgomery
    • , C. L. Scott
    • , J. M. Kel
    • , M. J. H. Girard-Madoux
    • , L. Martens
    • , T. F. P. Zangerle-Murray
    • , J. Ober-Blöbaum
    • , D. Lindenbergh-Kortleve
    • , J. N. Samsom
    • , S. Henri
    • , T. Lawrence
    • , Y. Saeys
    • , B. Malissen
    • , M. Dalod
    • , B. E. Clausen
    •  & A. McI. Mowat
  • Reviews |

    γδ T cells are found mainly in epithelial tissues, where they have crucial roles in tissue homeostasis and repair. Here, the authors describe how γδ T cells are activated and regulated in epithelial tissues, such as the skin and intestine, to mediate host microbial tolerance and provide protection against infection.

    • Morten M. Nielsen
    • , Deborah A. Witherden
    •  & Wendy L. Havran

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