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| Open AccessPhosphoprotein enriched in diabetes (PED/PEA15) promotes migration in hepatocellular carcinoma and confers resistance to sorafenib
- Cristina Quintavalle
- , Sravanth Kumar Hindupur
- & Matthias Sebastian Matter
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News and Commentary
| Open AccessEmergence of aspirin as a promising chemopreventive and chemotherapeutic agent for liver cancer
- Hongping Xia
- & Kam M Hui
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Original Article
| Open AccessIncreasing AR by HIF-2α inhibitor (PT-2385) overcomes the side-effects of sorafenib by suppressing hepatocellular carcinoma invasion via alteration of pSTAT3, pAKT and pERK signals
- Junjie Xu
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- & Xiujun Cai
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Original Article
| Open AccessTargeting redox homeostasis in rhabdomyosarcoma cells: GSH-depleting agents enhance auranofin-induced cell death
- Karoline Johanna Habermann
- , Leon Grünewald
- & Simone Fulda
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Original Article
| Open AccessTat-protein disulfide-isomerase A3: a possible candidate for preventing ischemic damage in the spinal cord
- Dae Young Yoo
- , Su Bin Cho
- & Seung Myung Moon
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Original Article
| Open AccessNDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy
- Hongsheng Wang
- , Wen Li
- & Yingqi Hua
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Original Article
| Open AccessTailored therapy guided by multichannel intraluminal impedance pH monitoring for refractory non-erosive reflux disease
- Nunzio Ranaldo
- , Giuseppe Losurdo
- & Alfredo Di Leo
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Original Article
| Open AccessApatinib promotes autophagy and apoptosis through VEGFR2/STAT3/BCL-2 signaling in osteosarcoma
- Kuisheng Liu
- , Tingting Ren
- & Wei Guo
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Original Article
| Open AccessThe erythropoietin-derived peptide MK-X and erythropoietin have neuroprotective effects against ischemic brain damage
- Seung-Jun Yoo
- , Bongki Cho
- & Cheil Moon
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Original Article
| Open AccessAn autocrine inflammatory forward-feedback loop after chemotherapy withdrawal facilitates the repopulation of drug-resistant breast cancer cells
- Deyong Jia
- , Li Li
- & Lisheng Wang
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Original Article
| Open AccessKilling two birds with one stone: dual blockade of integrin and FGF signaling through targeting syndecan-4 in postoperative capsular opacification
- Yingyan Qin
- , Yi Zhu
- & Mingxing Wu
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Original Article
| Open AccessAQP9-induced cell cycle arrest is associated with RAS activation and improves chemotherapy treatment efficacy in colorectal cancer
- Dandan Huang
- , Xingzhi Feng
- & Zihuan Yang
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Original Article
| Open AccessSimvastatin treatment boosts benefits of apoptotic cell infusion in murine lung fibrosis
- Ye-JI Lee
- , Meung-Joo Kim
- & Jihee Lee Kang
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Original Article
| Open AccessPrecision medicine for hepatocelluar carcinoma using molecular pattern diagnostics: results from a preclinical pilot study
- Rahul Agarwal
- , Yuan Cao
- & Gianluigi Giannelli
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Original Article
| Open AccessHuman cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death
- Emarndeena H Cheteh
- , Martin Augsten
- & Klas G Wiman
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Original Article
| Open AccessPromoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves as a potential theranostic target
- Ping Xie
- , Jun-Ping Yang
- & Chao-Nan Qian
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Original Article
| Open AccessCisplatin-enriching cancer stem cells confer multidrug resistance in non-small cell lung cancer via enhancing TRIB1/HDAC activity
- Lihui Wang
- , Xing Liu
- & Chunfu Wu
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Original Article
| Open AccessGanetespib synergizes with cyclophosphamide to improve survival of mice with autochthonous tumors in a mutant p53-dependent manner
- Evguenia M Alexandrova
- , Sulan Xu
- & Ute M Moll
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Original Article
| Open AccessThioridazine enhances sensitivity to carboplatin in human head and neck cancer cells through downregulation of c-FLIP and Mcl-1 expression
- Seung Un Seo
- , Hyuk Ki Cho
- & Taeg Kyu Kwon
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Original Article
| Open AccessDual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC
- Jae-Seon Lee
- , Joon H Kang
- & Soo-Youl Kim
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Original Article
| Open AccessCombined nifuroxazide and SAT05f therapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation
- Huijie Jia
- , Tiesuo Zhao
- & Kailin Xu
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Original Article
| Open AccessTherapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer’s disease models
- Stuart A Lipton
- , Tayebeh Rezaie
- & Nobuki Nakanishi
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Original Article
| Open Access1-Methyl-tryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis
- Chunyan Wei
- , Jie Mei
- & Xiaoyong Zhu
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Original Article
| Open AccessA mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC
- Nicole A Seebacher
- , Des R Richardson
- & Patric J Jansson
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Original Article
| Open AccessArginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury
- Esraa Shosha
- , Zhimin Xu
- & S Priya Narayanan
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Original Article
| Open AccessDe-ubiquitinating enzyme, USP11, promotes transforming growth factor β-1 signaling through stabilization of transforming growth factor β receptor II
- A M Jacko
- , L Nan
- & Y Zhao
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Review
| Open AccessThe control of male fertility by spermatid-specific factors: searching for contraceptive targets from spermatozoon’s head to tail
- Su-Ren Chen
- , Aalia Batool
- & Yi-Xun Liu
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Original Article
| Open AccessCysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation
- Álvaro de Mingo
- , Estefanía de Gregorio
- & Montserrat Marí
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Original Article
| Open AccessCnbp ameliorates Treacher Collins Syndrome craniofacial anomalies through a pathway that involves redox-responsive genes
- Mauro S Porcel de Peralta
- , Valeria S Mouguelar
- & Nora B Calcaterra
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Original Article
| Open AccessThrombospondin-1 signaling through CD47 inhibits cell cycle progression and induces senescence in endothelial cells
- Qi Gao
- , Kexin Chen
- & Yong-Guang Yang
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Original Article
| Open AccessLuteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model
- R Palombo
- , I Savini
- & A Terrinoni
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Original Article
| Open AccessFerroptosis is induced following siramesine and lapatinib treatment of breast cancer cells
- S Ma
- , E S Henson
- & S B Gibson
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Original Article
| Open AccessProton pump inhibitors protect mice from acute systemic inflammation and induce long-term cross-tolerance
- E Balza
- , P Piccioli
- & A Rubartelli
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Original Article
| Open AccessImmune-system-dependent anti-tumor activity of a plant-derived polyphenol rich fraction in a melanoma mouse model
- A Gomez-Cadena
- , C Urueña
- & S Fiorentino
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Original Article
| Open AccessSP6616 as a new Kv2.1 channel inhibitor efficiently promotes β-cell survival involving both PKC/Erk1/2 and CaM/PI3K/Akt signaling pathways
- T T Zhou
- , L L Quan
- & X Shen
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Original Article
| Open AccessDistal retinal ganglion cell axon transport loss and activation of p38 MAPK stress pathway following VEGF-A antagonism
- R Foxton
- , A Osborne
- & D T Shima
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Original Article
| Open AccessBIM mediates synergistic killing of B-cell acute lymphoblastic leukemia cells by BCL-2 and MEK inhibitors
- K Korfi
- , M Smith
- & R Marais
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Original Article
| Open AccessDihydroartemisinin attenuates lipopolysaccharide-induced osteoclastogenesis and bone loss via the mitochondria-dependent apoptosis pathway
- C Dou
- , N Ding
- & S Dong
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Original Article
| Open AccessFunctional genetics-directed identification of novel pharmacological inhibitors of FAS- and TNF-dependent apoptosis that protect mice from acute liver failure
- A P Komarov
- , E A Komarova
- & A V Gudkov
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Original Article
| Open AccessFrom fighting depression to conquering tumors: a novel tricyclic thiazepine compound as a tubulin polymerization inhibitor
- Y Mu
- , Y Liu
- & B Yan
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Original Article
| Open AccessNecroptosis in Niemann–Pick disease, type C1: a potential therapeutic target
- A Cougnoux
- , C Cluzeau
- & F D Porter
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Correspondence
| Open AccessRescue from early-onset hearing loss in a mouse model lacking the cyclin-dependent kinase inhibitor p19Ink4d
- Q Ma
- , M Grati
- & X Liu
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Original Article
| Open AccessRole of apoptosis-related miRNAs in resveratrol-induced breast cancer cell death
- R Venkatadri
- , T Muni
- & N Azad
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Original Article
| Open AccessDrug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation
- S Blondel
- , A-L Egesipe
- & X Nissan
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Original Article
| Open AccessStructural simulation of adenosine phosphate via plumbagin and zoledronic acid competitively targets JNK/Erk to synergistically attenuate osteoclastogenesis in a breast cancer model
- H Qiao
- , T-y Wang
- & T-t Tang
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Original Article
| Open AccessLow levels of Caspase-3 predict favourable response to 5FU-based chemotherapy in advanced colorectal cancer: Caspase-3 inhibition as a therapeutic approach
- L Flanagan
- , M Meyer
- & J H M Prehn
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News and Commentary
| Open AccessDeciphering the true antiproliferative target of an MK2 activation inhibitor in glioblastoma
- P E Brennan
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News and Commentary
| Open AccessCaspase 8 expression may determine the survival of women with ovarian cancer
- M Kim
- , L Hernandez
- & C M Annunziata
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Original Article
| Open AccessEMC6/TMEM93 suppresses glioblastoma proliferation by modulating autophagy
- X Shen
- , S Kan
- & Y Bai