Biophysical methods articles within Nature Methods

Featured

  • Brief Communication |

    A robot, algorithm and software for automated in vivo intracellular electrophysiology are reported that can automatically perform whole-cell patch clamping in the living mouse brain with quality comparable to that for a trained human experimenter.

    • Suhasa B Kodandaramaiah
    • , Giovanni Talei Franzesi
    •  & Craig R Forest

  • Research Highlights |

    Researchers in three independent laboratories develop nanoscale devices for network-level electrophysiology.

    • Erika Pastrana

  • News & Views |

    Single-molecule DNA sequencing takes an important step in a surprising new direction with a sequence-detection method based on magnetic tweezers.

    • Sten Linnarsson

  • Research Highlights |

    Microscopic optical devices make their way into living cells.

    • Daniel Evanko

  • Perspective |

    Authors present workflows for the analysis of metabolism phenotypes in mice and recommend analysis of covariance to asses body composition effects.

    • Matthias H Tschöp
    • , John R Speakman
    •  & Eric Ravussin

  • Research Highlights |

    Molecularly imprinted polymers act as 'smart' nucleants for protein crystallization.

    • Petya V Krasteva

  • Research Highlights |

    A single-molecule pull-down method provides a simple way for biologists to examine their favorite protein at the single-molecule level.

    • Daniel Evanko

  • Research Highlights |

    Illuminating cells through tiny transparent pillars permits spatially confined excitation of fluorescent molecules.

    • Natalie de Souza

  • Research Highlights |

    Analyzing brain signals from freely moving rodents in the wild is possible using a wireless neural recording system.

    • Erika Pastrana

  • Article |

    The combination of an ultrahigh-resolution dual optical trap with a confocal microscope allowed single-fluorophore detection of labeled oligonucleotide binding and simultaneous measurement of angstrom-scale changes in DNA tether extension.

    • Matthew J Comstock
    • , Taekjip Ha
    •  & Yann R Chemla

  • News & Views |

    The most abundant proteins in our cells are there to generate mechanical forces, and measurement of these forces has just become possible.

    • Xavier Trepat
    • , Ben Fabry
    •  & Jeffrey J Fredberg

  • Brief Communication |

    Stimulation of the light-activated cation channel channelrhodopsin-2 can depolarize heart muscle in vitro and in vivo, resulting in precise localized stimulation and constant prolonged depolarization of genetically targeted cardiomyocytes and cardiac tissue.

    • Tobias Bruegmann
    • , Daniela Malan
    •  & Philipp Sasse

  • Brief Communication |

    A microfluidic device containing a suspended microchannel resonator capable of measuring the mass of microscopic objects with femtogram resolution allows determination of bacteria, yeast and mammalian cell growth rates in less than one cell cycle by repeated measurement of the buoyant mass of single growing cells.

    • Michel Godin
    • , Francisco Feijó Delgado
    •  & Scott R Manalis

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