Featured
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Research Highlight |
Atomic force microscopy in super-resolution
Applying principles from super-resolution fluorescence microscopy increases the resolution of atomic force microscopy.
- Nina Vogt
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Technology Feature |
May mechanobiology work forcefully for you
Mechanical measurements would be easy if cells were homogeneous objects — they’re not.
- Vivien Marx
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Research Highlight |
AFM in a split second
A new development in high-speed atomic force microscopy enables microsecond resolution.
- Katarzyna M. Marcinkiewicz
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Methods in Brief |
Single-molecule imaging and force spectroscopy at extended depth
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Methods in Brief |
Measuring cellular mass with a picobalance
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Research Highlights |
Peering inside protein complexes with AFM
Atomic force microscopy is applied to image the location of chemical groups inside single protein complexes.
- Allison Doerr
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News & Views |
Toward high-throughput biomechanical phenotyping of single molecules
Two high-throughput single-molecule force spectroscopy platforms expand the reach of this technology for biomechanical molecular phenotyping.
- David Alsteens
- , Savaş Tay
- & Daniel J Müller
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Brief Communication |
From genes to protein mechanics on a chip
A microfluidic chip is used to construct a microarray of proteins, each labeled with a dockerin tag, for high-throughput single-molecule force spectroscopy experiments using a single cohesin-modified cantilever.
- Marcus Otten
- , Wolfgang Ott
- & Hermann E Gaub
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Tools in Brief |
Machining better cantilevers
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Research Highlights |
Unfolding to force
Applying tiny forces to single molecules at high speed reveals the mechanics behind molecule unfolding.
- Erika Pastrana
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Review Article |
Multiparametric imaging of biological systems by force-distance curve–based AFM
This Review of force-distance curve-based atomic force microscopy highlights the unique capabilities of the technique to simultaneously image the architecture of complex biological systems and map their physical, chemical and biological properties at nanometer resolution.
- Yves F Dufrêne
- , David Martínez-Martín
- & Daniel J Müller
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Research Highlights |
Upgrades for the AFM
Researchers continue to improve the performance of the atomic force microscope.
- Daniel Evanko
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Correspondence |
OpenFovea: open-source AFM data processing software
- Charles Roduit
- , Bhaskar Saha
- & Sandor Kasas
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Article |
Noncontact microrheology at acoustic frequencies using frequency-modulated atomic force microscopy
Noncontact, frequency-modulation atomic force microscopy (FM-AFM) can be used to measure the microrheological properties of soft samples at acoustic frequencies. The method will be useful for characterizing the elasticity and viscosity of tissues that detect or produce sound.
- Núria Gavara
- & Richard S Chadwick
Dissecting cell membrane tension dynamics and its effect on Piezo1-mediated cellular mechanosensitivity using force-controlled nanopipettes