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Sirtuins in stress response: guardians of the genome

Oncogene volume 33, pages 3764–3775 (2014)Cite this article

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Abstract

Sirtuins, a family of NAD+-dependent deacetylases, help organisms to respond to metabolic and genotoxic stress through diverse pathways, including metabolic homeostasis, cell survival pathways and cell-cycle control. Evidence accumulated over the past decade, including recent descriptions of mouse knockout models for each of the seven mammalian Sirtuins, suggests that protection of genome stability is among the most important roles of Sirtuins during stress response. Our current knowledge suggests that Sirtuins promote genome integrity through a variety of mechanisms, the majority of which involve a direct role in chromatin-related functions. Here, we review these mechanisms and discuss their implications for cell physiology and tumorigenesis.

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Acknowledgements

We wish to apologize to many colleagues whose work could not be cited in this review due to space limitations. We thank members of the Vaquero group for fruitful discussions. The Chromatin Biology group is supported by the Spanish Ministry of Science and Innovation (MICINN) grant SAF2011-25860, the Catalonian Government Agency AGAUR grant 2009SGR914 and a grant from the Association Française Ataxie de Friedreich (AFAF).

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  1. Chromatin Biology Laboratory, Cancer Epigenetics and Biology Program (PEBC), Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain

    L Bosch-Presegué & A Vaquero

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Bosch-Presegué, L., Vaquero, A. Sirtuins in stress response: guardians of the genome. Oncogene 33, 3764–3775 (2014). https://doi.org/10.1038/onc.2013.344

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