Evolving understanding of the role of helminths in the pathogenesis of autoimmunity has led to the development of novel therapeutic interventions that are showing promise in patients with immune-mediated diseases. Meanwhile, studies in animal models of arthritis suggest that these new products might also be applicable in autoimmune rheumatic disease.
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Unraveling the Hygiene Hypothesis of helminthes and autoimmunity: origins, pathophysiology, and clinical applications
BMC Medicine Open Access 13 April 2015
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Y. Shoenfeld declares that he is planning a clinical collaboration with Coronado Biosciences. D. B. Shor declares no competing interests.
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Supplementary Table 1
Clinical trials of helminth therapy as of December 2012 (DOC 71 kb)
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Shor, DA., Shoenfeld, Y. Will worms cure rheumatoid arthritis?. Nat Rev Rheumatol 9, 138–140 (2013). https://doi.org/10.1038/nrrheum.2013.3
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DOI: https://doi.org/10.1038/nrrheum.2013.3
