Methotrexate could benefit patients with chronic arthritis following chikungunya virus infection, according to the findings of a systematic review. The analysis included four retrospective studies, one prospective study and one non-blinded randomized clinical trial that evaluated methotrexate either as monotherapy or in combination with other treatments, highlighting the need for large-scale, carefully conducted studies, particularly blinded, randomized clinical trials.
References
Amaral, J. K. et al. Treatment of chronic chikungunya arthritis with methotrexate: a systematic review. Arthritis Care Res. https://doi.org/10.1002/acr.23519 (2018)
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Onuora, S. Methotrexate for chronic chikungunya arthritis?. Nat Rev Rheumatol 14, 122 (2018). https://doi.org/10.1038/nrrheum.2018.21
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DOI: https://doi.org/10.1038/nrrheum.2018.21