Acute inflammatory arthritis

Definition

Acute inflammatory arthritis is an umbrella term that describes a group of disorders characterized by joint inflammation involving the immune system and sudden, painful onset.

Latest Research and Reviews

  • Research | | open

    DEK is a secreted protein abundant in the synovia of patients with juvenile idiopathic arthritis. Here the authors show DEK is important for neutrophil extracellular trap formation and joint inflammation, and demonstrate therapeutic efficacy of DEK-targeting aptamers in a mouse model of arthritis.

    • Nirit Mor-Vaknin
    • , Anjan Saha
    • , Maureen Legendre
    • , Carmelo Carmona-Rivera
    • , M Asif Amin
    • , Bradley J. Rabquer
    • , Marta J. Gonzales-Hernandez
    • , Julie Jorns
    • , Smriti Mohan
    • , Srilakshmi Yalavarthi
    • , Dave A. Pai
    • , Kristine Angevine
    • , Shelley J. Almburg
    • , Jason S. Knight
    • , Barbara S. Adams
    • , Alisa E. Koch
    • , David A. Fox
    • , David R. Engelke
    • , Mariana J. Kaplan
    •  & David M. Markovitz
  • Reviews |

    The authors discuss the preclinical evidence that provides insights into the mechanisms, pathways and mediators that set in motion resolution of inflammation. The time is ripe to establish if, and how, this biology can inform therapeutic innovation in the context of chronic inflammatory diseases.

    • Mauro Perretti
    • , Dianne Cooper
    • , Jesmond Dalli
    •  & Lucy V. Norling
  • Reviews |

    Lyme borreliosis is a tick-borne disease that is caused by the bacteria Borrelia burgdorferi, Borrelia afzelii and Borrelia garinii. This Primer by Steere and colleagues discusses the epidemiology, mechanisms and management of Lyme borreliosis in North America and Europe.

    • Allen C. Steere
    • , Franc Strle
    • , Gary P. Wormser
    • , Linden T. Hu
    • , John A. Branda
    • , Joppe W. R. Hovius
    • , Xin Li
    •  & Paul S. Mead
  • Research | | open

    Type 2 immune responses are viewed as opposites of Type 1 and 17 responses. Here the authors show that activation of Type 2 immunity by helminth infection counteracts the development of inflammatory arthritis, a type 17-mediated pathology, via IL-4/IL-13- STAT6 signalling and eosinophil activation.

    • Zhu Chen
    • , Darja Andreev
    • , Katharina Oeser
    • , Branislav Krljanac
    • , Axel Hueber
    • , Arnd Kleyer
    • , David Voehringer
    • , Georg Schett
    •  & Aline Bozec

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