The microRNA miR-106b contributes to osteoporosis by negatively regulating osteoblast differentiation and bone formation via the bone morphogenic protein 2 (BMP2) signalling pathway, according to new research. In vitro, miR-106b negatively regulated osteogenic differentiation of mesenchymal stem cells. Mice with glucocorticoid-induced osteoporosis (GIOP) expressed higher levels of miR-106b than healthy mice, and silencing miR-106b signalling protected mice from GIOP by a combination of inhibiting bone resorption and promoting bone formation.
References
Liu, K. et al. Silencing miR-106b accelerates osteogenesis of mesenchymal stem cells and rescues against glucocorticoid-induced osteoporosis by targeting BMP2. Bone http://dx.doi.org/10.1016/j.bone.2017.01.014 (2017)
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Collison, J. miR-106b promotes osteoporosis in mice. Nat Rev Rheumatol 13, 130 (2017). https://doi.org/10.1038/nrrheum.2017.11
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DOI: https://doi.org/10.1038/nrrheum.2017.11
