In 2016, there have been several major scientific achievements related to myositis, including the discovery of a novel autoantibody and the relationship between autoantibodies and distinct clinical phenotypes. Advances in the way clinical trials are conducted have also led to breakthroughs in treatment strategies.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Immune cell profiles of idiopathic inflammatory myopathy patients expressed anti-aminoacyl tRNA synthetase or anti-melanoma differentiation-associated gene 5 autoantibodies
BMC Immunology Open Access 26 September 2023
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hozumi, H. et al. Comprehensive assessment of myositis-specific autoantibodies in polymyositis/dermatomyositis-associated interstitial lung disease. Respir. Med. 121, 91–99 (2016).
Pinal-Fernandez, I. et al. Longitudinal course of disease in a large cohort of myositis patients with autoantibodies recognizing the signal recognition particle. Arthritis Care Res. (Hoboken) http://dx.doi.org/10.1002/acr.22920 (2016).
Pinal-Fernandez, I. et al. Thigh muscle MRI in immune-mediated necrotising myopathy: extensive oedema, early muscle damage and role of anti-SRP autoantibodies as a marker of severity. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2016-210198 (2016).
Mescam-Mancini, L. et al. Anti-Jo-1 antibody-positive patients show a characteristic necrotizing perifascicular myositis. Brain 138, 2485–2492 (2015).
Pinal-Fernandez, I., Casciola-Rosen, L. A., Christopher-Stine, L., Corse, A. M. & Mammen, A. L. The prevalence of individual histopathologic features varies according to autoantibody status in muscle biopsies from patients with dermatomyositis. J. Rheumatol. 42, 1448–1454 (2015).
Albrecht, I. et al. Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies. J. Clin. Invest. 125, 4612–4624 (2015).
Ruperto, N. et al. Prednisone versus prednisone plus ciclosporin versus prednisone plus methotrexate in new-onset juvenile dermatomyositis: a randomised trial. Lancet 387, 671–678 (2016).
Munters, L. A. et al. Endurance exercise improves molecular pathways of aerobic metabolism in patients with myositis. Arthritis Rheumatol. 68, 1738–1750 (2016).
Euromyositis Network. The International Euromyositis Register www.euromyositis.eu (2016).
Acknowledgements
I.L. would like to thank H. Gunawardena of North Bristol NHS Trust, UK, for sharing information on clinical features in relation to myositis-specific autoantibodies. I.L. receives support from the Swedish Research Council (grant number K2014-52X-14045-14-3) and the Regional Agreement on Medical Training and Clinical Research (ALF) between Stockholm County Council and the Karolinska Institutet.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares that she has received research grants from Astra Zeneca and Bristol-Myers Squibb, and has served on the advisory board for Bristol-Myers Squibb and Idera Pharmaceuticals.
PowerPoint slides
Rights and permissions
About this article
Cite this article
Lundberg, I. New tools for diagnosis and therapy. Nat Rev Rheumatol 13, 74–76 (2017). https://doi.org/10.1038/nrrheum.2017.1
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrrheum.2017.1