Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Osteoarthritis

Bone as an imaging biomarker and treatment target in OA

Nature Reviews Rheumatology volume 12, pages 503–504 (2016)Cite this article

Subjects

Radiographic joint-space width is the standard structural outcome for trials in knee osteoarthritis (OA), but MRI provides comprehensive 3D insights into the multi-tissue pathology of OA and could provide a superior means of monitoring disease progression and response to treatment. A new study highlights bone as an imaging biomarker.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: 3D femur bone shape changes in osteoarthritis.

References

  1. Guermazi, A. et al. Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study). BMJ 345, e5339 (2012).

    Article  Google Scholar 

  2. Barr, A. J. et al. The relationship between three-dimensional knee MRI bone shape and total knee replacement — a case control study: data from the Osteoarthritis Initiative. Rheumatology (Oxford) http://dx.doi.org/10.1093/rheumatology/kew191 (2016).

  3. Neogi, T. et al. Magnetic resonance imaging-based three-dimensional bone shape of the knee predicts onset of knee osteoarthritis: data from the Osteoarthritis Initiative. Arthritis Rheum. 65, 2048–2058 (2013).

    Article  Google Scholar 

  4. Hunter, D. et al. Longitudinal validation of periarticular bone area and 3D shape as biomarkers for knee OA progression? Data from the FNIH OA Biomarkers Consortium. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2015-207602 (2015).

  5. Neogi, T., Conaghan, P. G., Niu, J., Zhang, Y. & Bowes, M. Trajectories of MRI-based 3-dimensional bone shape of the knee over 6 years: insights into knee osteoarthritis progression. Osteoarthritis Cartilage 24 (Suppl. 1), S57 (2016).

    Article  Google Scholar 

  6. Pelletier, J. P. et al. What is the predictive value of MRI for the occurrence of knee replacement surgery in knee osteoarthritis? Ann. Rheum. Dis. 72, 1594–1604 (2013).

    Article  Google Scholar 

  7. Bowes, M. A., De Souza, K., Vincent, G. R. & Conaghan, P. G. OA may not be as structurally heterogeneous as expected: shape analysis of all knees from the Osteoarthritis Initiative reveals a consistent pattern of bone shape change over 8 years. Osteoarthritis Cartilage 24, S254–S255 (2016).

    Article  Google Scholar 

  8. Reginster, J. Y. et al. Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial. Ann. Rheum. Dis. 72, 179–186 (2013).

    Article  CAS  Google Scholar 

  9. Laslett, L. L. et al. Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: a randomised controlled trial. Ann. Rheum. Dis. 71, 1322–1328 (2012).

    Article  CAS  Google Scholar 

  10. Callaghan, M. J. et al. A randomised trial of a brace for patellofemoral osteoarthritis targeting knee pain and bone marrow lesions. Ann. Rheum. Dis. 74, 1164–1170 (2015).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by NIH grant AR47785 (to T.N. and D.T.F.) and an Arthritis Foundation Innovative Research Grant (to T.N.).

Author information

Authors and Affiliations

  1. Boston University School of Medicine, 650 Albany Street, Clin Epi Unit, Suite X200, Boston, 02118, Massachusetts, USA

    Tuhina Neogi & David T. Felson

Authors
  1. Tuhina Neogi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David T. Felson
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tuhina Neogi.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Neogi, T., Felson, D. Bone as an imaging biomarker and treatment target in OA. Nat Rev Rheumatol 12, 503–504 (2016). https://doi.org/10.1038/nrrheum.2016.113

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrrheum.2016.113

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research