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Neurodevelopment

Pruning: a class I act

Nature Reviews Neuroscience volume 15, pages 280–281 (2014)Cite this article

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The authors used mice lacking the MHC class I molecules H2-Kb and H2-Db (KbDb−/− mice), the expression of which is known to be regulated by retinal waves. Data from whole-cell recordings in LGN slices indicated that KbDb−/− LGN neurons received input from more RGC axons than did wild-type LGN neurons. Moreover, the segregation of RGC axons into eye-specific LGN layers was impaired in KbDb−/− mice. Wild-type and KbDb−/− retinas showed similar retinal-wave activity, suggesting that H2-Kb and/or H2-Db act downstream of neuronal activity to regulate synapse pruning and eye-specific segregation.

the effects of the absence of these molecules at retino-geniculate synapses are not due to compromised immune function

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References

  1. Lee, H. et al. Synapse elimination and learning rules co-regulated by MHC class I H2-Db. Nature http://doi.org/10.1038/nature13154 (2014)

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  1. Leonie Welberg
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Blankenship, A. G. & Feller, M. B. Mechanisms underlying spontaneous patterned activity in developing neural circuits. Nature Rev. Neurosci. 11, 18–29 (2010)

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Welberg, L. Pruning: a class I act. Nat Rev Neurosci 15, 280–281 (2014). https://doi.org/10.1038/nrn3732

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