There have been no major improvements in the prevention or treatment of necrotizing enterocolitis (NEC) over the past several decades, and therefore a 'magic bullet' is urgently needed. However, new data demonstrate that disialyllacto-N-tetraose levels in breast milk can predict the risk of NEC, and these findings might provide a strategy for successful intervention.
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References
Frost, B. L., Modi, B. P., Jaksic, T. & Caplan, M. S. New medical and surgical insights into neonatal necrotizing enterocolitis: a review. JAMA Pediatr. 171, 83–88 (2017).
Lucas, A. & Cole, T. J. Breast milk and neonatal necrotising enterocolitis. Lancet 336, 1519–1523 (1990).
Autran, C. A. et al. Human milk oligosaccharide composition predicts risk of necrotising enterocolitis in preterm infants. Gut http://dx.doi.org/10.1136/gutjnl-2016-312819 (2017).
Moukarzel, S. & Bode, L. Human milk oligosaccharides and the preterm infant: a journey in sickness and in health. Clin. Perinatol. 44, 193–207 (2017).
Sawh, S. C., Deshpande, S., Jansen, S., Reynaert, C. J. & Jones, P. M. Prevention of necrotizing enterocolitis with probiotics: a systematic review and meta-analysis. PeerJ 4, e2429 (2016).
Jantscher-Krenn, E. et al. The human milk oligosaccharide disialyllacto-N-tetraose prevents necrotising enterocolitis in neonatal rats. Gut 61, 1417–1425 (2012).
Sylvester, K. G. & Moss, R. L. Urine biomarkers for necrotizing enterocolitis. Pediatr. Surg. Int. 31, 421–429 (2015).
Gordon, P. V., Swanson, J. R., MacQueen, B. C. & Christensen, R. D. A critical question for NEC researchers: can we create a consensus definition of NEC that facilitates research progress? Semin. Perinatol. 41, 7–14 (2017).
Underwood, M. A. et al. Human milk oligosaccharides in premature infants: absorption, excretion, and influence on the intestinal microbiota. Pediatr. Res. 78, 670–677 (2015).
Good, M. et al. The human milk oligosaccharide 2′-fucosyllactose attenuates the severity of experimental necrotising enterocolitis by enhancing mesenteric perfusion in the neonatal intestine. Br. J. Nutr. 116, 1175–1187 (2016).
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Caplan, M. Are human milk oligosaccharides the magic bullet for necrotizing enterocolitis?. Nat Rev Gastroenterol Hepatol 14, 394–395 (2017). https://doi.org/10.1038/nrgastro.2017.65
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DOI: https://doi.org/10.1038/nrgastro.2017.65
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