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  • Plants have uniquely adapted to manage endoplasmic reticulum stress triggered by protein misfolding. The authors review the dynamics of gene expression regulation underlying the unfolded protein response in plants, highlighting recent insights provided by systems-level approaches and omics data.

    • Dae Kwan Ko
    • Federica Brandizzi
    Review Article
  • A study in Nature Genetics identifies many regulators of genome-wide chromatin accessibility and then reports the mechanistic underpinnings for one of the identified transcription factors.

    • Henry Ertl
    Research Highlight
  • In this Review, Sayers et al. summarize findings from recent large-scale genetic epidemiology studies on the genetic underpinnings of chronic respiratory diseases. Furthermore, they outline how insights gained from such studies can improve treatment approaches.

    • Ian Sayers
    • Catherine John
    • Ian P. Hall
    Review Article
  • Hajk-Georg Drost recalls a 2010 publication that used a phylotranscriptomic approach to estimate the age of genes that contribute to the developmental transcriptome across animal species and inspired a subsequent study on the embryonic hourglass in plants.

    • Hajk-Georg Drost
    Journal Club
  • Kate Galloway highlights a paper by Kueh et al., who showed that the cell cycle indirectly influences concentrations of the transcription factor PU.1 to stabilize cell-fate trajectories in mice.

    • Kate E. Galloway
    Journal Club
  • In this Journal Club, Hajk-Georg Drost highlights a recent study by Pavlopoulos et al. that organizes proteins at tree-of-life scale using massively parallel graph-based clustering.

    • Hajk-Georg Drost
    Journal Club
  • Therapeutics that target long non-coding RNAs (lncRNAs) are promising treatments for cancer. In this Review, the authors discuss how technological advances have helped improve drug discovery pipelines for lncRNAs and overview their strengths and challenges as oncological therapeutics.

    • Michela Coan
    • Simon Haefliger
    • Rory Johnson
    Review Article
  • Carl G. de Boer highlights a recent paper by Lim et al. on the importance low-affinity transcription factor-binding sites for determining organismal phenotypes.

    • Carl G. de Boer
    Journal Club
  • Plant pangenomes have had a transformative impact on crop enhancement, biodiversity conservation and evolutionary research. This Review delves into the application of plant pangenomes for understanding trait diversity, aiding breeding, biodiversity classification and monitoring, and illuminating evolutionary innovations.

    • Mona Schreiber
    • Murukarthick Jayakodi
    • Martin Mascher
    Review Article
  • This Review discusses the evolutionary origin of Wnt signalling, its ancestral function and the characteristics of the primal Wnt ligand. It emphasizes the importance of genomic studies in pre-metazoan and basal metazoan species to understanding the evolutionary origin of signalling pathways.

    • Michaela Holzem
    • Michael Boutros
    • Thomas W. Holstein
    Review Article
  • This Review describes tools and approaches for characterizing short tandem repeats in the human genome from whole-genome sequencing data. Furthermore, the authors discuss how these recent developments have helped to better understand the effect of short tandem repeats on human health and disease.

    • Hope A. Tanudisastro
    • Ira W. Deveson
    • Daniel G. MacArthur
    Review Article
  • A study in Nature describes how single-cell expression data can be used to understand gene regulatory landscapes in bacteria.

    • Michael Attwaters
    Research Highlight
  • Amnon Koren recalls two papers from 2001 and 2002 that laid the foundations for a new field by using microarrays to measure DNA replication timing across the genome.

    • Amnon Koren
    Journal Club
  • Vincent Courdavault and Nicolas Papon highlight two articles in Nature, published in 2006 and 2013, that reported the biosynthesis of a complex natural plant product to treat malaria in engineered yeast.

    • Vincent Courdavault
    • Nicolas Papon
    Journal Club
  • Four papers in Nature describe how ancient European migration patterns have shaped the modern human genome.

    • Michael Attwaters
    Research Highlight