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Reproductive endocrinology

Maternal cholestasis and offspring metabolic abnormalities

Nature Reviews Endocrinology volume 9, pages 567–568 (2013)Cite this article

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Papacleovoulou and colleagues demonstrate that maternal cholestasis during pregnancy is associated with offspring adiposity and metabolic abnormalities, both in humans and in mice. This study reinforces the overwhelming evidence of the critical role of the in utero environment as a major determinant of adult health and disease.

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Figure 1: Maternal cholestasis and fetal lipid abnormalities.

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  1. David Geffen School of Medicine at UCLA, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, 90502, CA, USA

    Mina Desai & Michael G. Ross

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  1. Mina Desai
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  2. Michael G. Ross
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Correspondence to Mina Desai.

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The authors declare no competing financial interests.

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Desai, M., Ross, M. Maternal cholestasis and offspring metabolic abnormalities. Nat Rev Endocrinol 9, 567–568 (2013). https://doi.org/10.1038/nrendo.2013.165

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