In a new study, a dramatic decrease in the frequency of implantation, pregnancy and live birth is associated with increased urine levels of bisphenol A (BPA) in women undergoing in vitro fertilization (IVF). However, in women who consume soy-containing foods, the interfering effect of BPA on IVF success is negated.
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Bisphenol S negatively affects the meotic maturation of pig oocytes
Scientific Reports Open Access 28 March 2017
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References
Chavarro, J. E. et al. Soy intake modifies the relation between urinary bisphenol A concentrations and pregnancy outcomes among women undergoing assisted reproduction. J. Clin. Endocrinol. Metab. http://dx.doi.org/10.1210/jc.2015-3473, (2016).
Ehrlich, S. et al. Urinary bisphenol A concentrations and implantation failure among women undergoing in vitro fertilization. Environ. Health Perspect. 120, 978–983 (2012).
Peretz, J. et al. Bisphenol A and reproductive health: update of experimental and human evidence, 2007–2013. Environ. Health Perspect. 122, 775–786 (2014).
Vandenberg, L. N. et al. Low dose effects of bisphenol A: an integrated review of in vitro, laboratory animal and epidemiology studies. Endocr. Disruption 1, E1–E20 (2013).
vom Saal, F. S. & Welshons, W. V. Evidence that bisphenol A (BPA) can be accurately measured without contamination in human serum and urine, and that BPA causes numerous hazards from multiple routes of exposure. Mol. Cell. Endocrinol. 398, 101–113 (2014).
Muhlhauser, A. et al. Bisphenol A effects on the growing mouse oocyte are influenced by diet. Biol. Reprod. 80, 1066–1071 (2009).
Souter, I. et al. The association of bisphenol-A urinary concentrations with antral follicle counts and other measures of ovarian reserve in women undergoing infertility treatments. Reprod. Toxicol. 42, 224–231 (2013).
Dolinoy, D. C., Huang, D. & Jirtle, R. L. Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. Proc. Natl Acad. Sci. USA 104, 13056–13061 (2007).
Vandenberg, L. N. et al. Hormones and endocrine-disrupting chemicals: low dose effects and nonmonotonic dose responses. Endocr. Rev. 33, 378–455 (2012).
Newbold, R. R., Banks, E. P., Bullock, B. & Jefferson, W. N. Uterine adenocarcinoma in mice treated neonatally with genistein. Cancer Res. 61, 4325–4328 (2001).
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We thank Professor Patricia A. Hunt, Washington State University, Pullman, Washington, USA, for advice during the preparation of the manuscript.
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vom Saal, F., Welshons, W. Manmade and natural oestrogens: opposite effects on assisted reproduction. Nat Rev Endocrinol 12, 251–252 (2016). https://doi.org/10.1038/nrendo.2016.38
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DOI: https://doi.org/10.1038/nrendo.2016.38
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Bisphenol S negatively affects the meotic maturation of pig oocytes
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