Review
Nature Reviews Cancer 9, 773-784 (November 2009) | doi:10.1038/nrc2736
Article series: Epigenetics and genetics
Polycomb group proteins: navigators of lineage pathways led astray in cancer
Adrian P. Bracken1 & Kristian Helin2 About the authors
Abstract
The Polycomb group (PcG) proteins are transcriptional repressors that regulate lineage choices during development and differentiation. Recent studies have advanced our understanding of how the PcG proteins regulate cell fate decisions and how their deregulation potentially contributes to cancer. In this Review we discuss the emerging roles of long non-coding RNAs (ncRNAs) and a subset of transcription factors, which we call cell fate transcription factors, in the regulation of PcG association with target genes. We also speculate about how their deregulation contributes to tumorigenesis.
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Author affiliations
-
The Smurfit Institute of Genetics, Trinity College Dublin and The Adelaide & Meath Hospital, including the National Children's Hospital, Dublin, Ireland.
Email: adrian.bracken@tcd.ie -
Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, University of Copenhagen, Copenhagen 22009, Denmark.
Email: kristian.helin@bric.ku.dk
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