Table of contents
January 2006 Vol 6 No 1
From the editors
p1 | doi:10.1038/nrc1797
Research Highlights
Metastasis: Setting up shop
p3 | doi:10.1038/nrc1793
Chemoprevention: G-force
p4 | doi:10.1038/nrc1788
Trial Watch
Insulin and pancreatic cancer | Fibre and colorectal cancer
p4 | doi:10.1038/nrc1796
Leukaemia: Crisis talks
p5 | doi:10.1038/nrc1785
Carcinogenesis: A marked loss
p5 | doi:10.1038/nrc1794
Immunotherapy: Suppressing regulatory T cells
p6 | doi:10.1038/nrc1790
Signalling: Pathway paradox
p6 | doi:10.1038/nrc1795
Apoptosis: Taming Puma
p7 | doi:10.1038/nrc1786
Immunology: Suppressing T-lymphocyte cytotoxicity
p8 | doi:10.1038/nrc1787
Cachexia: Strong potential?
p8 | doi:10.1038/nrc1789
In the news
Cold–cancer link
p8 | doi:10.1038/nrc1792
In brief
Anticancer drugs | Cancer stem cells | Immunology | Senescence
p9 | doi:10.1038/nrc1791
Reviews
KLF4, p21 and context-dependent opposing forces in cancer
Benjamin D. Rowland & Daniel S. Peeper
p11 | doi:10.1038/nrc1780
Krüppel-like factors are transcriptional regulators that function both as tumour suppressors and oncogenes through their control of p21 expression. This might be an important nodal point of cell control for other factors that have opposing functions in cancer.
Paradoxical roles of the immune system during cancer development
Karin E. de Visser, Alexandra Eichten & Lisa M. Coussens
p24 | doi:10.1038/nrc1782
This review examines how recent insights, gained from mouse models, have improved our understanding of the contradictory role of adaptive and innate leukocytes in cancer development.
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
Saverio Minucci & Pier Giuseppe Pelicci
p38 | doi:10.1038/nrc1779
How have the data from the initial clinical trials of histone deacetylase inhibitors (HDACi) improved our understanding of how these drugs work? And what key facts do we still need to understand about the biology of HDACi?
A PANorama of PAX genes in cancer and development
Ewan J. D. Robson, Shu-Jie He & Michael R. Eccles
p52 | doi:10.1038/nrc1778
The transcription factors of the Pax gene family are important in growth regulation and, therefore, the prevention of malignant growth. This review examines their roles in embryogenesis and how these can be subverted to contribute to tumorigenesis.
Predicting the future burden of cancer
Freddie Bray & Bjørn Møller
p63 | doi:10.1038/nrc1781
Predicting cancer occurrence is a difficult task. However, if predictions are accurate, they can be useful to health planners trying to optimize resources, and to assess the impact of planned interventions. How are predictions made and what are the challenges?
Perspectives
Timeline
Epidemiology — identifying the causes and preventability of cancer?
Graham A. Colditz, Thomas A. Sellers & Edward Trapido
p75 | doi:10.1038/nrc1784
In the 25 years since Doll and Peto published their groundbreaking report on the causes of cancers and strategies for prevention, there have been many additional epidemiological studies of cancer incidence. What do we now know about opportunities for cancer prevention?
Science and society
Locus-specific mutation databases: pitfalls and good practice based on the p53 experience
Thierry Soussi, Chikashi Ishioka, Mireille Claustres & Christophe Béroud
p83 | doi:10.1038/nrc1783
Accessible information about the presence and effect of specific mutations in cancer-causing genes is essential, but keeping track of these mutations is not simple. This article, using p53 as an example, highlights the difficulties involved in maintaining mutation databases.
Correspondence
Correspondence: Time to harness the pro-apoptotic property of NF
B?
Senthil K. Radhakrishnan & Sitharthan Kamalakaran
| doi:10.1038/nrc1588-c1