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Does everyone develop covert cancer?

Do we all develop a covert cancer as we age?

Abstract

Around one in three individuals, if they live long enough, will have a confirmed clinical diagnosis of overt cancer, and there is increasing evidence that many of us — I contend all of us — develop covert cancer.

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References

  1. Sakr, W. A. et al. The frequency of carcinoma and intraepithelial neoplasia of the prostate in young male patients. J. Urol. 150, 379–385 (1993).

    Article  CAS  PubMed  Google Scholar 

  2. Welch, H. G. & Black, W. C. Using autopsy series to estimate the disease “reservoir” for ductal carcinoma in situ of the breast: how much more breast cancer can we find? Ann. Int. Med. 127, 1023–1028 (1997).

    Article  CAS  PubMed  Google Scholar 

  3. Mori, H. et al. Chromosome translocations and covert leukemic clones are generated during normal fetal development. Proc. Natl Acad. Sci. USA 99, 8242–8247 (2002).

    Article  CAS  Google Scholar 

  4. Ståhl, P. L. et al. Sun-induced nonsynonymous p53 mutations are extensively accumulated and tolerated in normal appearing human skin. J. Invest. Dermatol. 131, 504–508 (2011).

    Article  PubMed  Google Scholar 

  5. Welch, J. S. et al. The origin and evolution of mutations in acute myeloid leukemia. Cell 150, 264–278 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Greaves, M. Darwinian medicine: a case for cancer. Nature Rev. Cancer 7, 213–221 (2007).

    Article  CAS  Google Scholar 

  7. Bissell, M. J. & Hines, W. C. Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nature Med. 17, 320–329 (2011).

    Article  CAS  PubMed  Google Scholar 

  8. Esserman, L. J., Thompson, I. M. Jr & Reid, B. Overdiagnosis and overtreatment in cancer: an opportunity for improvement. J. Am. Med. Assoc. 310, 797–798 (2013).

    Article  CAS  Google Scholar 

  9. Maley, C. C. et al. Genetic clonal diversity predicts progression to esophageal adenocarcinoma. Nature Genet. 38, 468–473 (2006).

    Article  CAS  PubMed  Google Scholar 

  10. Kostadinov, R. L. et al. NSAIDs modulate clonal evolution in Barrett's esophagus. PLoS Genet. 9, e1003553 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Correspondence to Mel Greaves.

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Greaves, M. Does everyone develop covert cancer?. Nat Rev Cancer 14, 209–210 (2014). https://doi.org/10.1038/nrc3703

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