Abstract
Post-transcriptional RNA modifications were discovered several decades ago, but the reversible nature of RNA modifications has only recently been discovered. Owing to technological advances, knowledge of epitranscriptomic marks and their writers, readers and erasers has recently advanced tremendously. Here we focus on the roles of the dynamic methylation and demethylation of internal adenosines in mRNA in germ cells and pluripotent stem cells.
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References
Duechler, M., Leszczyńska, G., Sochacka, E. & Nawrot, B. Cell. Mol. Life Sci. 73, 3075–3095 (2016).
Patil, D.P. et al. Nature 537, 369–373 (2016).
Zhao, B.S., Roundtree, I.A. & He, C. Nat. Rev. Mol. Cell Biol. http://dx.doi.org/10.1038/nrm.2016.132 (2016).
Darnell, J.E. Jr. RNA 19, 443–460 (2013).
Jia, G. et al. Nat. Chem. Biol. 7, 885–887 (2011).
Zheng, G. et al. Mol. Cell 49, 18–29 (2013).
Li, X. et al. Nat. Chem. Biol. 12, 311–316 (2016).
Dominissini, D. et al. Nature 530, 441–446 (2016).
Susor, A., Jansova, D., Anger, M. & Kubelka, M. Cell Tissue Res. 363, 69–84 (2016).
Shah, J.C. & Clancy, M.J. Mol. Cell. Biol. 12, 1078–1086 (1992).
Sripati, C.E., Groner, Y. & Warner, J.R. J. Biol. Chem. 251, 2898–2904 (1976).
Clancy, M.J., Shambaugh, M.E., Timpte, C.S. & Bokar, J.A. Nucleic Acids Res. 30, 4509–4518 (2002).
Schwartz, S. et al. Cell 155, 1409–1421 (2013).
Dominissini, D. et al. Nature 485, 201–206 (2012).
Wang, X. et al. Nature 505, 117–120 (2014).
Ping, X.-L. et al. Cell Res. 24, 177–189 (2014).
Hongay, C.F., Grisafi, P.L., Galitski, T. & Fink, G.R. Cell 127, 735–745 (2006).
Hongay, C.F. & Orr-Weaver, T.L. Proc. Natl. Acad. Sci. USA 108, 14855–14860 (2011).
Wang, Y. et al. Nat. Cell Biol. 16, 191–198 (2014).
Geula, S. et al. Science 347, 1002–1006 (2015).
Batista, P.J. et al. Cell Stem Cell 15, 707–719 (2014).
Bradley, A., Evans, M., Kaufman, M.H. & Robertson, E. Nature 309, 255–256 (1984).
Reubinoff, B.E., Pera, M.F., Fong, C.Y., Trounson, A. & Bongso, A. Nat. Biotechnol. 18, 399–404 (2000).
Zhao, B.S. & He, C. Genome Biol. 16, 43 (2015).
Niwa, H., Miyazaki, J. & Smith, A.G. Nat. Genet. 24, 372–376 (2000).
Filipczyk, A. et al. Nat. Cell Biol. 17, 1235–1246 (2015).
Alarcón, C.R., Lee, H., Goodarzi, H., Halberg, N. & Tavazoie, S.F. Nature 519, 482–485 (2015).
Roost, C. et al. J. Am. Chem. Soc. 137, 2107–2115 (2015).
Ke, S. et al. Genes Dev. 29, 2037–2053 (2015).
Alarcón, C.R. et al. Cell 162, 1299–1308 (2015).
Lin, S., Choe, J., Du, P., Triboulet, R. & Gregory, R.I. Mol. Cell 62, 335–345 (2016).
Wickramasinghe, V.O. & Laskey, R.A. Nat. Rev. Mol. Cell Biol. 16, 431–442 (2015).
Wang, X. et al. Cell 161, 1388–1399 (2015).
Chen, T. et al. Cell Stem Cell 16, 289–301 (2015).
Aguilo, F. et al. Cell Stem Cell 17, 689–704 (2015).
Tuck, M.T., James, C.B., Kelder, B. & Kopchick, J.J. Cancer Lett. 103, 107–113 (1996).
Garcia-Closas, M. et al. Nat. Genet. 45, 392–398, e1–e2 (2013).
Iles, M.M. et al. Nat. Genet. 45, 428–432, e1 (2013).
Zhang, C. et al. Proc. Natl. Acad. Sci. USA 113, E2047–E2056 (2016).
Ougland, R. et al. Mol. Cell 16, 107–116 (2004).
Liu, F. et al. Cell 167, 816–828.e16 (2016).
Haag, S. et al. EMBO J. 35, 2104–2119 (2016).
van den Born, E. et al. Nat. Commun. 2, 172 (2011).
Fu, Y. et al. Angew. Chem. Int. Ed. Engl. 49, 8885–8888 (2010).
Van Haute, L. et al. Nat. Commun. 7, 12039 (2016).
Kirchner, S. & Ignatova, Z. Nat. Rev. Genet. 16, 98–112 (2015).
Dahl, J.A. et al. Nature 537, 548–552 (2016).
Li, L., Zheng, P. & Dean, J. Development 137, 859–870 (2010).
Acknowledgements
The writing of this Commentary was supported by the Oslo University Hospital, the Norwegian Cancer Society and the Norwegian Research Council.
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Klungland, A., Dahl, J., Greggains, G. et al. Reversible RNA modifications in meiosis and pluripotency. Nat Methods 14, 18–22 (2017). https://doi.org/10.1038/nmeth.4111
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DOI: https://doi.org/10.1038/nmeth.4111
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