Volume 7 Issue 2, February 2001
The lymphatic vasculature is required for transport of extravasated cells, fluid, and macromolecules back in to the circulation, and is also involved in tumor metastasis. In this issue, three articles (pages 186, 192 and 199) investigate the role of vascular endothelial growth factores (VEGF) in developmental and tumor-induced lymphangiogenesis. Mäkinen et al. (page 199) show that transgenic mice overexpressing a soluble form of the VEGF-receptor (VEGFR-3) do not undergo lymphangiogenesis. The cover image shows the vasculature (blue) of a normal intestine (top) as compared to that of a transgenic mouse (bottom) at the age of two weeks.
Editorial
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