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Reply to “Overstimulation of the α1B-adrenergic receptor causes a “seizure plus” syndrome”

Nature Medicine volume 7, pages 132–133 (2001)Cite this article

Perez replies

Wenning and colleagues report that our transgenic model of systemically overexpressed α1B-adrenergic receptors1 is not an accurate model of MSA, and they suggest that the main features are those of a seizure phenotype. Though we do agree that seizures are uncommonly seen in MSA, the seizure phenotype is consistent with the lesions produced and may represent a mouse manifestation of MSA. The mouse cerebral cortex has a much higher α1B-advenergic receptor density than humans which would explain the greater degeneration. Moreover, there are now several reports in humans of extensive cerebral cortex degeneration associated with MSA (refs. 8–10).

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  1. Department of Molecular Cardiology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Dianne Perez

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Perez, D. Reply to “Overstimulation of the α1B-adrenergic receptor causes a “seizure plus” syndrome”. Nat Med 7, 132–133 (2001). https://doi.org/10.1038/84531

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