An eagerly awaited prostate cancer susceptibility gene has been announced. But does the candidate live up to expectations?
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Carter, B.S., Beaty, T.H., Steinberg, G.D., Childs, B. & Walsh, P.C. Mendelian inheritance of familial prostate cancer. Proc. Natl. Acad. Sci. USA 89, 3367–3371 (1992).
Tavtigian, S.V. et al. A strong candidate prostate cancer susceptibility gene at chromosome 17p. Nature Genet. 27, 172–180 (2001).
Ross, R.K. et al. Androgen metabolism and prostate cancer: establishing a model of genetic susceptibility. Cancer Res. 58, 4497–4504 (1998).
Wadelius, M., Andersson, A.O., Johansson, J.E., Wadelius C. & Rane, E. Prostate cancer associated with CYP17 genotype. Pharmacogenet. 9, 635–639 (1999).
Irvine, R.A., Yu, M.C., Ross, R.K. & Coetzee, G.A. The CAG and GGC microsatellites of the androgen receptor gene are in linkage disequilibrium in men with prostate cancer. Cancer Res. 55, 1937–1940 (1995).
Mononen, N. et al. Two percent of Finnish prostate cancer patients have a germ-line mutation in the hormone-binding domain of the androgen receptor gene. Cancer Res. 60, 6479–6481 (2000).
Xue, W. et al. Susceptibility to prostate cancer: interaction between genotypes at the androgen receptor and prostate-specific antigen loci. Cancer Res. 60, 839–841 (2000).
Rebbeck, T.R. et al. Association of HPC2/ELAC2 genotypes and prostate cancer. Am. J. Hum. Genet. 67, 1014–1019 (2000).
Smith, J.R. et al. Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search. Science 274, 1371–1374 (1996).
Berthon, P. et al. Predisposing gene for early-onset prostate cancer, localized on chromosome 1q42.2-43. Am. J. Hum. Genet. 62, 1416–1424 (1998).
Gibbs, M. et al. Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. Am. J. Hum. Genet. 64, 776–787 (1999).
Xu, J. et al. Evidence for a prostate cancer susceptibility locus on the X chromosome. Nature Genet. 20, 175–179 (1998).
Gayther, S.A. et al. The frequency of germ-line mutations in the breast cancer predisposition genes BRCA1 and BRCA2 in familial prostate cancer. Cancer Res. 60, 4513–4518 (2000).
Berry, R. et al. Evidence for a prostate cancer-susceptibility locus on chromosome 20. Am. J. Hum. Genet. 67, 82–91 (2000).
Xu, L.L. et al. A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate. Genomics 66, 257–263 (2000).
Gibbs, M. et al. A genomic scan of families with prostate cancer identifies multiple regions of interest. Am. J. Hum. Genet. 67, 100–109 (2000).
Suarez, B.K. et al. A genome screen of multiplex sibships with prostate cancer. Am. J. Hum. Genet. 66, 933–944 (2000).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Borg, Å. Hereditary prostate cancer: a new piece of the puzzle. Nat Med 7, 153–155 (2001). https://doi.org/10.1038/84585
Issue Date:
DOI: https://doi.org/10.1038/84585