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The Brockham Group was convened to investigate the growing problem of antibiotic resistance and to develop a strategy to improve our understanding and management of this phenomenon. Here they present their recommendations.
Vaccines composed of cross-reactive strains of mycobacteria that share antigens with the organism causing leprosy provoke an immune response in leprosy patients.
The Leverhulme lectures were established this year to commemorate the centenary of the Liverpool School of Tropical Medicine. Fotis Kafatos, the European Molecular Biology Laboratory, discusses how molecular genetic analysis is helping to elucidate the interaction between mosquitoes and malaria parasites, the subject of the first Leverhulme lecture.
Treating parkinsonian rats with cloned, transgenic bovine fetal tissue demonstrates the potential therapeutic benefits of using cloned tissue in xenotransplantation (pages 569–574).
A mouse model of Gorlin's syndrome implicates mutations in patched and upregulation of insulin growth factor 2 in the etiology of rhabdomyosarcoma (pages 619–622).