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Antibiotic resistance - what can we do?

The Brockham Group was convened to investigate the growing problem of antibiotic resistance and to develop a strategy to improve our understanding and management of this phenomenon. Here they present their recommendations.

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References

  1. WHO Scientific Working Croup on Monitoring and Management of Bacterial Resistance to Antimicrobial Agents. WHO, Geneva WHO/CDS/BV I 7,1–33 (1995).

  2. Cohen, M.L. Epidemiology of drug resistance: implications for a post-antimicrobial era. Science 257,1050–1055 (1992).

    Article  CAS  Google Scholar 

  3. Tomasz, A. Multiple-antibiotic-resistant pathogenic bacteria. A report on the Rockefeller University workshop. N. Engl. j. Med. 330,1247–1251 (1994).

    Article  CAS  Google Scholar 

  4. Felmingham, D., Gruneberg, R.N. & The Alexander Project Group. A multicentre collaborative study of the antimicrobial susceptibility of community-acquired, lower respiratory tract pathogens 1992-1993: j. Antimicrob. Chemother. 38, suppl A: 1–57 (1996).

    Article  CAS  Google Scholar 

  5. Tomasz, A. Multiple-antibiotic-resistant pathogenic bacteria. A report on the Rockefeller University workshop. N. Engl. j. Med. 330,1247–1251 (1994).

    Article  CAS  Google Scholar 

  6. Klugman, K.P. The clinical relevance of in-vitro resistance to penicillin, ampicillin, amoxycillin and alternative agents for the treatment of community-acquired pneumonia. J. Antimicrob. Chemother. 38, suppl A: 133–140 (1996).

    Article  CAS  Google Scholar 

  7. Seppala, H. et al. Finish study group for antimicrobial resistance. The effect of changes in the consumption of macrolide antibiotics on erythromycin resistance in group A streptococci in Finland. N. Engl. j Med. 337,441 (1997).

    Article  CAS  Google Scholar 

  8. Pallares, R. et al. Resistance to penicillin and cephalosporin and mortality from severe pneumococcal pneumonia in Barcelona, Spain. N. Engl. J. Med. 333,474–80 (1995).

    Article  CAS  Google Scholar 

  9. Pinner, W.R. et al. Trends in infectious diseases mortality in the United States. IAMA 275,189–93(1996).

    Article  CAS  Google Scholar 

  10. Sack, R.B., Rahman, M., Yunus, M. & Khan, E.H. Antimicrobial resistance in organisms causing diarrheal disease. Clin. Inf. Dis. 24, suppl 1: SI 02–5 (1997).

    Google Scholar 

  11. Bax, R.P. Antibiotic resistance: A view from the pharmaceutical industry. Clin. Inf. Dis. 24, suppl 1: SI51–3 (1997).

    Article  Google Scholar 

  12. Chopra, I., Hodgson, J., Metcalf, B., Poste, G. New approaches to the control of infections caused by antibiotic-resistant bacteria. An Industry Perspective. IAMA 275, 401–3(1996).

    Article  CAS  Google Scholar 

  13. Nystrom, P.O. et al. Proposed definitions for diagnosis, severity scoring, stratification and outcome for trials on intra abdominal infection. World. J. Sura 14,148–58 (1990).

    Article  CAS  Google Scholar 

  14. Bax, R.P. Clinical trials and the pharmaceutical industry. J. Antimocrob. Chemother 21,278–80(1988).

    Article  CAS  Google Scholar 

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Bax, R., Anderson, R., Crew, J. et al. Antibiotic resistance - what can we do?. Nat Med 4, 545–546 (1998). https://doi.org/10.1038/nm0598-545

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