Abstract
The discovery that HIV requires a chemokine co-receptor to invade host cells has prompted many investigations into therapeutic strategies that target these receptors in an attempt to block HIV entry. In this review, Scott Cairns and Patricia D'Souza discuss these potentially powerful approaches and how they complement existing antiretroviral drug therapy.
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D'Souza, M.P. & Harden, V.A. Nature Med. 2, 1293–1300 (1996).
Dragic, T. et al. Nature 381, 667–673 (1996).
Deng, H. et al. Nature 381, 661–666 (1996).
Alkhatib, C. et al. Science 272, 1955–1958 (1996).
Doranz, B.J. et al. Cell 85, 1149–1158 (1996).
Choe, H. et al. Cell 85, 1135–1148 (1996).
Berger, E.A. et al. Nature 391, 240 (1998).
Marcon, L. et al. J .Virol. 71, 2522–2527 (1997).
Edinger, A.L. et al. Proc. Natl. Acad. Sci. USA 94, 4005–4010 (1997).
Feng, Y., Broder, C.C. Kennedy, P.E. & Berger, E.A. Science 272, 872–877 (1996).
Simmons, G. et al. J. Virol. 70, 8355–8360 (1996).
Connor, R.I., Sheridan, K.E., Ceradini, D., Choe, S. & Landau, N.R. J. Exp. Med. 185, 621–628 (1997).
Liu, R. et al. Cell 86, 367–377 (1996).
Samson, M. et al. Nature 382, 722–725 (1996).
Dean, M. et al. Science 273, 1856–1862 (1996).
Huang, Y. et al. Nature Med. 2, 1240–1243 (1996).
Zimmerman, P.A. et al. Mol. Med. 3, 22–35 (1997).
Mummidi, S., Ahuja, S.S., McDaniel, B., & Ahuja, S.K. J. Biol. Chem. 272, 30662–30671 (1997).
Moore, J.P. Science 276, 51–52 (1997).
Wu, L., Paxton et al. J. Exp. Med. 185, 1681–1691 (1997).
Winkler, C. et al. Science 279, 389–393 (1998).
Levine, B.L. et al. Science 272, 1939–1943 (1996).
Carroll, R.G. et al. Science 276, 273–276 (1997).
Chen, J.D., Bai, X., Yang, A.G. Cong, Y. & Chen, S.Y. Nature Med. 3, 1110–1116 (1997).
Yang, A.G., Bai, X., Huang, X.F., Yao, C. & Chen, S.Y. Proc. Natl. Acad. Sci. USA (1997).
Van Zee, K.J. et al. J. Immunol. 148, 1746–1752 (1992).
Chen, J.D., Yang, Q., Yang, A.G., Marasco, W.A. & Chen, S.Y. Hum. Gene Ther. 7, 1515–1525 (1996).
Marasco, W.A., Haseltine, W.A. & Chen, S.Y. Proc. Natl. Acad. Sci. USA 90, 7889–7893 (1993).
Inouye, R.T. et al. J. Virol. 71, 4071–4078 (1997).
Sarver, N. et al. Science 247, 1222–1225 (1990).
Yu, M. et al. Proc. Natl. Acad. Sci. USA 90, 6340–6344 (1993).
Mhashilkar, A.M., Biswas, D.K., LaVecchio, J., Pardee, A.B. & Marasco, W.A. J. Virol. 71, 6486–6494 (1997).
Duan, L., Bagasra, O., Laughlin, M.A., Oakes, J.W. & Pomerantz, R.J. Proc. Natl. Acad. Sci. USA 91, 5075–5079 (1994).
Hinkula, J. et al, J. Acquir. Immune. Defic. Syndr. 7, 940–951 (1994).
Gunthard, H.F. et al. J. Infect. Dis. 170, 1384–1393 (1994).
Endres, M.J. et al. Cell 87, 745–756 (1996).
Wu, L. et al. J. Exp. Med. 186, 1373–1381 (1997).
Mebatsion, T., Finke, S., Weiland, F. & Conzelmann, K.K. Cell 90, 841–847 (1997).
Schnell, M.J., Johnson, J.E., Buonocore, L. & Rose, J.K. Cell 90, 849–857 (1997).
Endres, M. Jaffer, S., Haggarty, B., et al. Science 278, 1462–1464 (1997).
Nolan, G.P. Cell 90, 821–824 (1997).
Amara, A. et al. Nature Med. 4, 72–77 (1997).
Cocchi, F. et al. Science 270, 1811–1815 (1995).
Bleul, C.C. et al. Nature 382, 829–833 (1996).
Oberlin, E. et al. Nature 382, 833–835 (1996).
Tiffany, H.L. et al. J. Exp. Med. 186, 165–170 (1997).
Pal, R. et al. Science 278, 695–698 (1997).
Trkola, A. et al. J. Virol. 72, 396–404 (1998).
Schmidtmayerova, H., Sherry, B. & Bukrinsky, M. Nature 382, 767 (1996).
Arenzana-Seisdedos, F. et al. Nature 383, 400 (1996).
Simmons, G. et al. Science 276, 276–279 (1997).
Granelli-Piperno, A. et al. J. Exp. Med. 184, 2433–2438 (1996).
Murakami, H. et al. J. Exp. Med. 186, 1389–1393 (1997).
Doranz, B.J. et al. J. Exp. Med. 186, 1395–1400 (1997).
Donzella, G.A. et al. Nature Med. 4, 72–77 (1998).
Schols, D., Struyf, S., Van Damme, J., Este, J.A., Henson, G., Si De Clercq, E. J. Exp. Med. 186, 1383–1388 (1997).
De Clercq, E. et al. Proc. Natl. Acad. Sci. USA 89, 5286–5290 (1992).
De Clercq, E. et al. Antimicrob. Agents Chemother. 38, 668–674 (1994).
Datema, R. et al. Antimicrob. Agents Chemother. 40, 750–754 (1996).
Zhu, T. et al. Science 261, 1179–1181 (1993).
Schuitemaker, H. et al. J. Virol. 66, 1354–1360 (1992).
Moore, J. Trkola, A. AIDS Res. Hum. Retro. 13, 733–736 (1997).
Zhang, L., Huang, Y., He, T., Cao, Y. & Ho, D.D. Nature 383, 768 (1996).
Scarlatti, G. et al. Nature Med. 3, 1259–1265 (1997).
Hesselgesser, J. et al. Curr. Biol. 7, 112–121 (1997).
Edinger, A.L. et al. Proc. Natl. Acad. Sci. USA, in the press.
Willett, B.J., Picard, L., Hosie, M.J., Turner, J.D., Adema, K. & Clapham, P. R. J. Virol. 71, 6407–6415 (1997).
Horuk, R., Hesselgesser, J., Zhou, Y. et al. J. Biol. Chem. 273, 386–391 (1998).
Liao, F. et al. J. Exp. Med. 185, 2015–2023 (1997).
Deng, H.K., Unutmaz, D., Kewalramani, V.N. & Littman, D.R. Nature 388, 296–300 (1997).
Alkhatib, G., Liao, F., Berger, E.A., Farber, J.M., & Peden, K.W. Nature 388, 238 (1997).
Farzan, M. et al. J. Exp. Med. 186, 405–411 (1997).
Reeves, J.D. et al. Virology 231, 130–134 (1997).
Rucker, J. et al. J. Virol. 71, 8999–9007 (1997).
Pleskoff, O., Treboute, C., Brelot, A., Heveker, N., Seman, M. & Alizon, M. Science 276, 1874–1878 (1997).
Bazan, J.F. et al. Nature 385, 640–644 (1997).
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Cairns, J., D'Souza, M. Chemokines and HIV-1 second receptors: The therapeutic connection. Nat Med 4, 563–568 (1998). https://doi.org/10.1038/nm0598-563
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DOI: https://doi.org/10.1038/nm0598-563
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