Despite intensive study, the mechanisms of pathogenesis in inflammatory bowel diseases (IBDs) remain poorly understood. An innate T helper type 17 (TH17) response that requires nucleotide oligomerization domain (Nod)-like receptors and is primed by commensal bacteria is now shown to be crucial for controlling intestinal bacterial pathogens in a mouse model (pages 837–844). Thus, dysregulation of this protective immune response may be important in IBD development.
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Hornef, M., Josenhans, C. A Nod toward understanding Crohn's pathology. Nat Med 17, 785–787 (2011). https://doi.org/10.1038/nm0711-785
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DOI: https://doi.org/10.1038/nm0711-785