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Rheumatic heart disease (RHD) is a chronic auto-inflammatory reaction to group A streptococcal infection, and frequently occurs in individuals from the South Pacific. This study finds a novel association between an immunoglobulin heavy chain allele and risk of RHD in Pacific Islanders and South Asians.
A detailed study of E. coli strains that were isolated from the urine of women shows that bladder colonization does not require previously defined virulence factors but is linked to the differential regulation of core functions.