In recent years, Salmonella has tainted foods including spinach, peanut butter and eggs, sickening thousands of people in the process. But researchers hope that these microbes will make headlines for a better reason: curing cancer. They want to harness Salmonella's special ability to thrive in oxygen-deprived conditions to target regions of solid tumors that are normally immune to conventional therapies. Elie Dolgin reports.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Pawelek J.M., Low K.B. & Bermudes D. Cancer Res. 15, 4537–4544 (1997).
Kasinskas, R.W. & Forbes, N.S. Biotechnol. Bioeng. 94, 710–721 (2006).
Kasinskas, R.W. & Forbes, N.S. Cancer Res. 67, 3201–3209 (2007).
Leschner, S. et al. PLoS One 4, e6692 (2009).
Saccheri, F. et al. Sci. Trans. Med. 2, 44ra57 (2010).
Arrach, N., Zhao, M., Porwollik, S., Hoffman, R.M. & McClelland, M. Cancer Res. 68, 4827–4832 (2008).
Zhao, M. et al. Proc. Natl. Acad. Sci. USA 102, 755–760 (2005).
Zhao, M. et al. Cancer Res. 66, 7647–7652 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dolgin, E. From spinach scare to cancer care. Nat Med 17, 273–275 (2011). https://doi.org/10.1038/nm0311-273
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm0311-273
This article is cited by
-
Salmonella Typhimurium as an Anticancer Therapy: Recent Advances and Perspectives
Current Clinical Microbiology Reports (2019)