Cancer therapy

Definition

Cancer therapy describes the treatment of cancer in a patient, often with surgery, chemotherapy and/or radiotherapy. Targeted therapies are also available for some cancer types. A cancer patient might receive many different types of therapy, including those aimed at relieving the symptoms of cancer, such as pain.

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Latest Research and Reviews

  • Reviews |

    Chimeric antigen receptor (CAR)-T-cell therapies are showing great promise in the treatment of cancer, particularly B-cell malignancies, but are associated with characteristic, potentially fatal toxicities, principally cytokine-release syndrome, CAR-T-cell-related encephalopathy syndrome, and haemophagocytic lymphohistiocytosis/macrophage-activation syndrome. Herein, the CAR-T-cell-therapy-associated TOXicity (CARTOX) Working Group, comprising multidisciplinary investigators from various institutions with clinical experience in the use of a range of CAR-T-cell platforms, review these acute toxicities and provide monitoring, grading, and management recommendations.

    • Sattva S. Neelapu
    • , Sudhakar Tummala
    • , Partow Kebriaei
    • , William Wierda
    • , Cristina Gutierrez
    • , Frederick L. Locke
    • , Krishna V. Komanduri
    • , Yi Lin
    • , Nitin Jain
    • , Naval Daver
    • , Jason Westin
    • , Alison M. Gulbis
    • , Monica E. Loghin
    • , John F. de Groot
    • , Sherry Adkins
    • , Suzanne E. Davis
    • , Katayoun Rezvani
    • , Patrick Hwu
    •  & Elizabeth J. Shpall
  • Research | | open

    Bacterial outer membrane vesicles (OMVs) contain immunogens but no study has yet examined their potential in treating cancer. Here, the authors demonstrate that OMVs can suppress established tumours and prevent tumour metastasis by an interferon-γ mediated antitumor response.

    • Oh Youn Kim
    • , Hyun Taek Park
    • , Nhung Thi Hong Dinh
    • , Seng Jin Choi
    • , Jaewook Lee
    • , Ji Hyun Kim
    • , Seung-Woo Lee
    •  & Yong Song Gho
  • Research |

    A silent single-nucleotide variant (SNV) affecting the transcription of a long noncoding RNA (lncRNA EGFR-AS1) within the EGFR coding region alters the EGFR isoform ratio and modulates oncogene addiction and response to EGFR tyrosine kinase inhibitors in squamous-cell cancers. Proof-of-concept validation in patients supports the notion that this SNV and levels of the lncRNA could be used to predict response to therapy in a clinical setting. These results, together with findings by Bal et al., uncover the functional role of noncoding RNAs in modulating the response to targeted therapies in cancer.

    • Daniel S W Tan
    • , Fui Teen Chong
    • , Hui Sun Leong
    • , Shen Yon Toh
    • , Dawn P Lau
    • , Xue Lin Kwang
    • , Xiaoqian Zhang
    • , Gopinath M Sundaram
    • , Gek San Tan
    • , Mei Mei Chang
    • , Boon Tin Chua
    • , Wan Teck Lim
    • , Eng Huat Tan
    • , Mei Kim Ang
    • , Tony K H Lim
    • , Prabha Sampath
    • , Balram Chowbay
    • , Anders J Skanderup
    • , Ramanuj DasGupta
    •  & N Gopalakrishna Iyer
  • Research | | open

    The clinical management of metastatic melanoma requires predictors of the response to checkpoint blockade. Here, the authors use immunological assays to identify potential prognostic/predictive biomarkers in circulating blood cells and in tumor-infiltrating lymphocytes from patients with resected stage III melanoma.

    • N. Jacquelot
    • , M. P. Roberti
    • , D. P. Enot
    • , S. Rusakiewicz
    • , N. Ternès
    • , S. Jegou
    • , D. M. Woods
    • , A. L. Sodré
    • , M. Hansen
    • , Y. Meirow
    • , M. Sade-Feldman
    • , A. Burra
    • , S. S. Kwek
    • , C. Flament
    • , M. Messaoudene
    • , C. P. M. Duong
    • , L. Chen
    • , B. S. Kwon
    • , A. C. Anderson
    • , V. K. Kuchroo
    • , B. Weide
    • , F. Aubin
    • , C. Borg
    • , S. Dalle
    • , O. Beatrix
    • , M. Ayyoub
    • , B. Balme
    • , G. Tomasic
    • , A. M. Giacomo
    • , M. Maio
    • , D. Schadendorf
    • , I. Melero
    • , B. Dréno
    • , A. Khammari
    • , R. Dummer
    • , M. Levesque
    • , Y. Koguchi
    • , L. Fong
    • , M. Lotem
    • , M. Baniyash
    • , H. Schmidt
    • , I. M. Svane
    • , G. Kroemer
    • , A. Marabelle
    • , S. Michiels
    • , A. Cavalcanti
    • , M. J. Smyth
    • , J. S. Weber
    • , A. M. Eggermont
    •  & L. Zitvogel

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