Volume 2 Issue 8, August 2001

Artistic interpretation of rheumatoid arthritis synovium (black). A recent mouse model of arthritis highlighted glucose-6-phosphate isomerase (GPI) as a target for both autoreactive antibodies and T cells. Now Ditzel and colleagues show that GPI (green in the tissue section) is a target of antibodies in the human disease, as well. Fluorescence micrograph of a synovium from article on page 746. Red denotes propridium iodide–stained nuclei. Painting is acrylic on paper by Michael Malicki.

Editorial

Accidentally informed

Editorial 01 Aug 2001

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Correspondence

New nomenclature for MHC receptors

P. André
R. Biassoni
M. J. Wilson
Correspondence 01 Aug 2001

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Commentary

Ruby anniversary: forty years of thymus immunology research

Historical insight: For years the function of the thymus remained a mystery. Investigations into murine leukemia led, 40 years ago next month, to the first connection of the thymus to immune function. We asked Jacques Miller to put this immunological milestone in perspective.

Jacques F. A. P. Miller
Commentary 01 Aug 2001

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News & Views

SAP: natural inhibitor or grand SLAM of T cell activation?

Identification of SH2D1A as the defective gene in X-linked lymphoproliferative syndrome highlighted the importance of SAP in the regulation of T cell activation. New data suggest an alternative explanation for how SAP controls signaling.

Kim E. Nichols
Gary A. Koretzky
Carl H. June
News & Views 01 Aug 2001
Lung Krüpple-like factor: a quintessential player in T cell quiescence

The molecular events behind T cell quiescence are poorly understood. Evidence is now emerging that the transcription factor LKLF can potentially programme cells to a resting state in a c-Myc–dependent manner.

James P. Di Santo
News & Views 01 Aug 2001
TCR avidity: it's not how strong you make it, it's how you make it strong

Unlike the BCR, the TCR cannot undergo affinity maturation. However, T cells respond with greater sensitivity to antigen during an immune response. New evidence suggests T cells undergo avidity maturation to enhance T cell responsiveness in the absence of changes in intrinsic affinity.

David H. Margulies
News & Views 01 Aug 2001
The mucosal milieu creates tolerogenic dendritic cells and T_R1 and T_H3 regulatory cells

Certain types of regulatory T cells are preferentially induced at mucosal surfaces to maintain tolerance. However, the mechanisms involved in their induction are unclear. New evidence suggests DCs orchestrate this mucosal tolerogenic immune response.

Howard L. Weiner
News & Views 01 Aug 2001

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Round-up

Immunology highlights from the recent literature

Round-up 01 Aug 2001

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Review Article

Toll-like receptors: critical proteins linking innate and acquired immunity

Shizuo Akira
Kiyoshi Takeda
Tsuneyasu Kaisho
Review Article 01 Aug 2001

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Article

Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product

Sylvain Latour
Gerald Gish
André Veillette
Article 01 Aug 2001
The β-catenin–TCF-1 pathway ensures CD4⁺CD8⁺ thymocyte survival

Vassilios Ioannidis
Friedrich Beermann
Werner Held
Article 01 Aug 2001
Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc–dependent pathway

Anne F. Buckley
Chay T. Kuo
Jeffrey M. Leiden
Article 01 Aug 2001
CD4⁺ T cell effectors can become memory cells with high efficiency and without further division

Hui Hu
Gail Huston
Susan L. Swain
Article 01 Aug 2001
Functional avidity maturation of CD8⁺ T cells without selection of higher affinity TCR

Mark K. Slifka
J. Lindsay Whitton
Article 01 Aug 2001
Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen

Kay L. Medina
Karla P. Garrett
Paul W. Kincade
Article 01 Aug 2001
Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen

Omid Akbari
Rosemarie H. DeKruyff
Dale T. Umetsu
Article 01 Aug 2001
CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein

Ralph A. Tripp
Les P. Jones
Larry J. Anderson
Article 01 Aug 2001
Contribution of the innate immune system to autoimmune myocarditis: a role for complement

Ziya Kaya
Marina Afanasyeva
Noel R. Rose
Article 01 Aug 2001
Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human disease

Monica Schaller
Dennis R. Burton
Henrik J. Ditzel
Article 01 Aug 2001

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Volume 2 Issue 8, August 2001

Editorial

Accidentally informed

Correspondence

New nomenclature for MHC receptors

Commentary

Ruby anniversary: forty years of thymus immunology research

News & Views

SAP: natural inhibitor or grand SLAM of T cell activation?

Lung Krüpple-like factor: a quintessential player in T cell quiescence

TCR avidity: it's not how strong you make it, it's how you make it strong

The mucosal milieu creates tolerogenic dendritic cells and T_R1 and T_H3 regulatory cells

Round-up

Immunology highlights from the recent literature

Review Article

Toll-like receptors: critical proteins linking innate and acquired immunity

Article

Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product

The β-catenin–TCF-1 pathway ensures CD4⁺CD8⁺ thymocyte survival

Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc–dependent pathway

CD4⁺ T cell effectors can become memory cells with high efficiency and without further division

Functional avidity maturation of CD8⁺ T cells without selection of higher affinity TCR

Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen

Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen

CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein

Contribution of the innate immune system to autoimmune myocarditis: a role for complement

Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human disease

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