The methyltransferase Ezh2, an epigenetic regulator associated with tumor-cell metastasis, also methlyates the cytoplasmic integrin adaptor talin. This modification inhibits the binding of talin to F-actin, which enhances the migration and invasion of dendritic cells and neutrophils.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Deb, G., Singh, A.K. & Gupta, S. Mol. Cancer Res. 12, 639–653 (2014).
Gunawan, M. et al. Nat. Immunol. 16, 505–516 (2015).
Choudhary, C. et al. Science 325, 834–840 (2009).
Deakin, N.O. & Turner, C.E. J. Cell Biol. 206, 395–413 (2014).
Kaluza, D. et al. EMBO J. 30, 4142–4156 (2011).
Marino, G. et al. Mol. Cell (2014).
Martínez, J.A., Milagro, F.I., Claycombe, K.J. & Schalinske, K.L. Adv. Nutr. 5, 71–81 (2014).
Su, I.H. et al. Cell 121, 425–436 (2005).
Tien, C.L. et al. Development 142, 722–731 (2015).
Lämmermann, T. et al. Nature 453, 51–55 (2008).
Wehrle-Haller, B. Curr. Opin. Cell Biol. 24, 569–581 (2012).
Fischer, K.D. et al. Curr. Biol. 8, 554–562 (1998).
Simonson, W.T., Franco, S.J. & Huttenlocher, A.J. Immunol 177, 7707–7714 (2006).
Garcia-Bernal, D., Parmo-Cabanas, M., Dios-Esponera, A., Samaniego, R. & Hernán Pérez de la Ossa, D. Immunity. 31, 953–964 (2009).
Zingg, D. et al. Nat. Commun. 6, 6051 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Wehrle-Haller, B. Cytoplasmic methylation fuels leukocyte invasion. Nat Immunol 16, 441–443 (2015). https://doi.org/10.1038/ni.3142
Published:
Issue Date:
DOI: https://doi.org/10.1038/ni.3142