Innate immune cells

Definition

Innate immune cells are white blood cells that mediate innate immunity and include basophils, dendritic cells, eosinophils, Langerhans cells, mast cells, monocytes and macrophages, neutrophils and NK cells.

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Latest Research and Reviews

  • Research |

    Huot et al. investigate the differences in natural killer (NK) cells in lymph nodes during pathogenic and nonpathogenic simian immunodeficiency virus (SIV) infection of cynomolgus macaques and African green monkeys (AGMs), respectively. Their findings suggest that NK cells are specifically recruited to follicles in AGMs and regulate SIV replication in the lymph node.

    • Nicolas Huot
    • , Beatrice Jacquelin
    • , Thalia Garcia-Tellez
    • , Philippe Rascle
    • , Mickaël J Ploquin
    • , Yoann Madec
    • , R Keith Reeves
    • , Nathalie Derreudre-Bosquet
    •  & Michaela Müller-Trutwin
  • Research |

    Gillet and colleagues find that infection with a gammaherpesvirus confers strong and lasting protection against airway allergy through the replacement of lung-resident alveolar macrophages with recruited regulatory monocytes of bone marrow origin.

    • Bénédicte Machiels
    • , Mickael Dourcy
    • , Xue Xiao
    • , Justine Javaux
    • , Claire Mesnil
    • , Catherine Sabatel
    • , Daniel Desmecht
    • , François Lallemand
    • , Philippe Martinive
    • , Hamida Hammad
    • , Martin Guilliams
    • , Benjamin Dewals
    • , Alain Vanderplasschen
    • , Bart N Lambrecht
    • , Fabrice Bureau
    •  & Laurent Gillet
  • Research | | open

    Damage-associated molecular patterns (DAMP) are important mediators of innate immunity. Here the authors show that N-myc and STAT interactor (NMI) and interferon-induced protein 35 (IFP35) act as DAMPs to promote inflammation by activating macrophages via the Toll-like receptor 4 and NF-κB pathways.

    • Zhikai Xiahou
    • , Xiangli Wang
    • , Juan Shen
    • , Xiaoxiao Zhu
    • , Feng Xu
    • , Rong Hu
    • , Deyin Guo
    • , Henan Li
    • , Yong Tian
    • , Yingfang Liu
    •  & Huanhuan Liang
  • Research | | open

    Zbtb16-encoded transcription factor PLZF directs the differentiation of multiple innate and innate-like cell lineages, but how Zbtb16 itself is regulated remains unclear. Here the authors show, using CRISPR gene editing, ATAC-seq and ChIP-seq, that specific Runx1-bound enhancer elements critically modulate lineage-dependent expressions of PLZF.

    • Ai-Ping Mao
    • , Isabel E. Ishizuka
    • , Darshan N. Kasal
    • , Malay Mandal
    •  & Albert Bendelac
  • Research | | open

    Molecular mechanisms of macrophage-mediated regulation of artery growth in response to ischemia are poorly understood. Here the authors show that vascular endothelium controls macrophage maturation and differentiation via Notch signaling, which in turn promotes arteriogenesis and ischemic tissue recovery.

    • Kashyap Krishnasamy
    • , Anne Limbourg
    • , Tamar Kapanadze
    • , Jaba Gamrekelashvili
    • , Christian Beger
    • , Christine Häger
    • , Vladimir J. Lozanovski
    • , Christine S. Falk
    • , L. Christian Napp
    • , Johann Bauersachs
    • , Matthias Mack
    • , Hermann Haller
    • , Christian Weber
    • , Ralf H. Adams
    •  & Florian P. Limbourg
  • Research | | open

    TLR9 is highly expressed by plasmacytoid dendritic cells and detects nucleic acids, but to discriminate between host and microbial nucleic acids TLR9 is sorted into different endosomal compartments. Here the authors show that BAD-LAMP limits type 1 interferon responses by sorting TLR9 to late endosomal compartments.

    • Alexis Combes
    • , Voahirana Camosseto
    • , Prudence N’Guessan
    • , Rafael J. Argüello
    • , Julie Mussard
    • , Christophe Caux
    • , Nathalie Bendriss-Vermare
    • , Philippe Pierre
    •  & Evelina Gatti

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