Innate immune cells

Definition

Innate immune cells are white blood cells that mediate innate immunity and include basophils, dendritic cells, eosinophils, Langerhans cells, mast cells, monocytes and macrophages, neutrophils and NK cells.

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Latest Research and Reviews

  • Reviews |

    Effective drug treatments for intracerebral haemorrhage (ICH) are still lacking. However, therapies that target microglial phenotype switching might soon become available for affected patients. Here, Wang and colleagues summarize key advances in understanding of microglial function after ICH, including modulators of microglial function and interactions with other cells.

    • Xi Lan
    • , Xiaoning Han
    • , Qian Li
    • , Qing-Wu Yang
    •  & Jian Wang
  • Research | | open

    Long-term consumption of a calorie-rich diet persistently activates brain microglia. Here, the authors show that microglial activity in mouse brains oscillates daily in conjunction with feeding, and that TNFα, secreted by activated microglia, induces mitochondrial stress in satiety-promoting POMC neurons.

    • Chun-Xia Yi
    • , Marc Walter
    • , Yuanqing Gao
    • , Soledad Pitra
    • , Beata Legutko
    • , Stefanie Kälin
    • , Clarita Layritz
    • , Cristina García-Cáceres
    • , Maximilian Bielohuby
    • , Martin Bidlingmaier
    • , Stephen C. Woods
    • , Alexander Ghanem
    • , Karl-Klaus Conzelmann
    • , Javier E. Stern
    • , Martin Jastroch
    •  & Matthias H. Tschöp
  • Research |

    Microglia are the tissue-resident macrophages of the brain. Ouyang and colleagues show the ER-resident transmembrane protein NRROS is necessary for proper development and function of microglia. Mice lacking NRROS exhibit neurologic defects and die prematurely.

    • Kit Wong
    • , Rajkumar Noubade
    • , Paolo Manzanillo
    • , Naruhisa Ota
    • , Oded Foreman
    • , Jason A Hackney
    • , Brad A Friedman
    • , Rajita Pappu
    • , Kimberly Scearce-Levie
    •  & Wenjun Ouyang
    Nature Immunology 18, 633–641
  • Research |

    Targeting NETosis alleviates type-2 immunopathology induced by rhinovirus infection in a mouse model of airway hypersensitivity, and correlative data suggest that a similar mechanism may operate in human rhinovirus-exacerbated asthma.

    • Marie Toussaint
    • , David J Jackson
    • , Dawid Swieboda
    • , Anabel Guedán
    • , Theodora-Dorita Tsourouktsoglou
    • , Yee Man Ching
    • , Coraline Radermecker
    • , Heidi Makrinioti
    • , Julia Aniscenko
    • , Michael R Edwards
    • , Roberto Solari
    • , Frédéric Farnir
    • , Venizelos Papayannopoulos
    • , Fabrice Bureau
    • , Thomas Marichal
    •  & Sebastian L Johnston

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